Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity
AuthorChan, FL; Vinod, B; Novy, K; Schittenhelm, RB; Huang, C; Udugama, M; Nunez-Iglesias, J; Lin, JI; Hii, L; Chan, J; ...
Source TitleNucleic Acids Research
PublisherOXFORD UNIV PRESS
University of Melbourne Author/sNunez-Iglesias, Juan
AffiliationMedicine Dentistry & Health Sciences
Document TypeJournal Article
CitationsChan, F. L., Vinod, B., Novy, K., Schittenhelm, R. B., Huang, C., Udugama, M., Nunez-Iglesias, J., Lin, J. I., Hii, L., Chan, J., Pickett, H. A., Daly, R. J. & Wong, L. H. (2017). Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity. NUCLEIC ACIDS RESEARCH, 45 (21), pp.12340-12353. https://doi.org/10.1093/nar/gkx904.
Access StatusOpen Access
AURKB (Aurora Kinase B) is a serine/threonine kinase better known for its role at the mitotic kinetochore during chromosome segregation. Here, we demonstrate that AURKB localizes to the telomeres in mouse embryonic stem cells, where it interacts with the essential telomere protein TERF1. Loss of AURKB function affects TERF1 telomere binding and results in aberrant telomere structure. In vitro kinase experiments successfully identified Serine 404 on TERF1 as a putative AURKB target site. Importantly, in vivo overexpression of S404-TERF1 mutants results in fragile telomere formation. These findings demonstrate that AURKB is an important regulator of telomere structural integrity.
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