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dc.contributor.authorFiorito, G
dc.contributor.authorPolidoro, S
dc.contributor.authorDugue, P-A
dc.contributor.authorKivimaki, M
dc.contributor.authorPonzi, E
dc.contributor.authorMatullo, G
dc.contributor.authorGuarrera, S
dc.contributor.authorAssumma, MB
dc.contributor.authorGeorgiadis, P
dc.contributor.authorKyrtopoulos, SA
dc.contributor.authorKrogh, V
dc.contributor.authorPalli, D
dc.contributor.authorPanico, S
dc.contributor.authorSacerdote, C
dc.contributor.authorTumino, R
dc.contributor.authorChadeau-Hyam, M
dc.contributor.authorStringhini, S
dc.contributor.authorSeveri, G
dc.contributor.authorHodge, AM
dc.contributor.authorGiles, GG
dc.contributor.authorMarioni, R
dc.contributor.authorLinner, RK
dc.contributor.authorO'Halloran, AM
dc.contributor.authorKenny, RA
dc.contributor.authorLayte, R
dc.contributor.authorBaglietto, L
dc.contributor.authorRobinson, O
dc.contributor.authorMcCrory, C
dc.contributor.authorMilne, RL
dc.contributor.authorVineis, P
dc.date.accessioned2020-12-18T02:42:42Z
dc.date.available2020-12-18T02:42:42Z
dc.date.issued2017-11-24
dc.identifierpii: 10.1038/s41598-017-16391-5
dc.identifier.citationFiorito, G., Polidoro, S., Dugue, P. -A., Kivimaki, M., Ponzi, E., Matullo, G., Guarrera, S., Assumma, M. B., Georgiadis, P., Kyrtopoulos, S. A., Krogh, V., Palli, D., Panico, S., Sacerdote, C., Tumino, R., Chadeau-Hyam, M., Stringhini, S., Severi, G., Hodge, A. M. ,... Vineis, P. (2017). Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-16391-5.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/255465
dc.description.abstractLow socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSocial adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-017-16391-5
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
melbourne.identifier.nhmrc209057
dc.rights.licenseCC BY
melbourne.elementsid1281416
melbourne.contributor.authorMilne, Roger
melbourne.contributor.authorSeveri, Gianluca
melbourne.contributor.authorHodge, Allison
melbourne.contributor.authorGiles, Graham
melbourne.contributor.authorDugue, Pierre-Antoine
melbourne.contributor.authorBaglietto, Laura
dc.identifier.eissn2045-2322
melbourne.identifier.fundernameidNHMRC, 209057
melbourne.accessrightsOpen Access


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