Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.

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    Author
    Sud, A; Thomsen, H; Law, PJ; Försti, A; Filho, MIDS; Holroyd, A; Broderick, P; Orlando, G; Lenive, O; Wright, L; ...
    Date
    2017-12-01
    Source Title
    Nature Communications
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Giles, Graham
    Affiliation
    Melbourne School of Population and Global Health
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    Document Type
    Journal Article
    Citations
    Sud, A., Thomsen, H., Law, P. J., Försti, A., Filho, M. I. D. S., Holroyd, A., Broderick, P., Orlando, G., Lenive, O., Wright, L., Cooke, R., Easton, D., Pharoah, P., Dunning, A., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K. ,... Houlston, R. S. (2017). Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.. Nat Commun, 8 (1), pp.1892-. https://doi.org/10.1038/s41467-017-00320-1.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255503
    DOI
    10.1038/s41467-017-00320-1
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711884
    Abstract
    Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.

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