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dc.contributor.authorGrice, ID
dc.contributor.authorRogers, KL
dc.contributor.authorGriffiths, LR
dc.date.accessioned2020-12-18T02:50:30Z
dc.date.available2020-12-18T02:50:30Z
dc.date.issued2011-01-01
dc.identifierpii: nep213
dc.identifier.citationGrice, I. D., Rogers, K. L. & Griffiths, L. R. (2011). Isolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguus. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, pp.1-8. https://doi.org/10.1093/ecam/nep213.
dc.identifier.issn1741-427X
dc.identifier.urihttp://hdl.handle.net/11343/255519
dc.description.abstractInfusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant's anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6  μ M, in comparison to aspirin, with an IC50 value of 46.1  μ M. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions.
dc.languageEnglish
dc.publisherHINDAWI LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleIsolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguus
dc.typeJournal Article
dc.identifier.doi10.1093/ecam/nep213
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleEvidence-Based Complementary and Alternative Medicine
melbourne.source.volume2011
melbourne.source.pages1-8
dc.rights.licenseCC BY
melbourne.elementsid1190223
melbourne.contributor.authorRogers, Kelly
dc.identifier.eissn1741-4288
melbourne.accessrightsOpen Access


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