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    The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species

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    Author
    Han, H; Baumann, K; Casewell, NR; Ali, SA; Dobson, J; Koludarov, I; Debono, J; Cutmore, SC; Rajapakse, NW; Jackson, TNW; ...
    Date
    2017-02-01
    Source Title
    Toxins
    Publisher
    MDPI
    University of Melbourne Author/s
    Jackson, Timothy
    Affiliation
    Pharmacology and Therapeutics
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Han, H., Baumann, K., Casewell, N. R., Ali, S. A., Dobson, J., Koludarov, I., Debono, J., Cutmore, S. C., Rajapakse, N. W., Jackson, T. N. W., Jones, R., Hodgson, W. C., Fry, B. G. & Kuruppu, S. (2017). The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species. TOXINS, 9 (2), https://doi.org/10.3390/toxins9020067.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255523
    DOI
    10.3390/toxins9020067
    Abstract
    Fish venoms are often poorly studied, in part due to the difficulty in obtaining, extracting, and storing them. In this study, we characterize the cardiovascular and neurotoxic effects of the venoms from the following six species of fish: the cartilaginous stingrays Neotrygon kuhlii and Himantura toshi, and the bony fish Platycephalus fucus, Girella tricuspidata, Mugil cephalus, and Dentex tumifrons. All venoms (10-100 μg/kg, i.v.), except G. tricuspidata and P. fuscus, induced a biphasic response on mean arterial pressure (MAP) in the anesthetised rat. P. fucus venom exhibited a hypotensive response, while venom from G. tricuspidata displayed a single depressor response. All venoms induced cardiovascular collapse at 200 μg/kg, i.v. The in vitro neurotoxic effects of venom were examined using the chick biventer cervicis nerve-muscle (CBCNM) preparation. N. kuhlii, H. toshi, and P. fucus venoms caused concentration-dependent inhibition of indirect twitches in the CBCNM preparation. These three venoms also inhibited responses to exogenous acetylcholine (ACh) and carbachol (CCh), but not potassium chloride (KCl), indicating a post-synaptic mode of action. Venom from G. tricuspidata, M. cephalus, and D. tumifrons had no significant effect on indirect twitches or agonist responses in the CBCNM. Our results demonstrate that envenoming by these species of fish may result in moderate cardiovascular and/or neurotoxic effects. Future studies aimed at identifying the molecules responsible for these effects could uncover potentially novel lead compounds for future pharmaceuticals, in addition to generating new knowledge about the evolutionary relationships between venomous animals.

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