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dc.contributor.authorHan, H
dc.contributor.authorBaumann, K
dc.contributor.authorCasewell, NR
dc.contributor.authorAli, SA
dc.contributor.authorDobson, J
dc.contributor.authorKoludarov, I
dc.contributor.authorDebono, J
dc.contributor.authorCutmore, SC
dc.contributor.authorRajapakse, NW
dc.contributor.authorJackson, TNW
dc.contributor.authorJones, R
dc.contributor.authorHodgson, WC
dc.contributor.authorFry, BG
dc.contributor.authorKuruppu, S
dc.date.accessioned2020-12-18T02:51:01Z
dc.date.available2020-12-18T02:51:01Z
dc.date.issued2017-02-01
dc.identifierpii: toxins9020067
dc.identifier.citationHan, H., Baumann, K., Casewell, N. R., Ali, S. A., Dobson, J., Koludarov, I., Debono, J., Cutmore, S. C., Rajapakse, N. W., Jackson, T. N. W., Jones, R., Hodgson, W. C., Fry, B. G. & Kuruppu, S. (2017). The Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species. TOXINS, 9 (2), https://doi.org/10.3390/toxins9020067.
dc.identifier.issn2072-6651
dc.identifier.urihttp://hdl.handle.net/11343/255523
dc.description.abstractFish venoms are often poorly studied, in part due to the difficulty in obtaining, extracting, and storing them. In this study, we characterize the cardiovascular and neurotoxic effects of the venoms from the following six species of fish: the cartilaginous stingrays Neotrygon kuhlii and Himantura toshi, and the bony fish Platycephalus fucus, Girella tricuspidata, Mugil cephalus, and Dentex tumifrons. All venoms (10-100 μg/kg, i.v.), except G. tricuspidata and P. fuscus, induced a biphasic response on mean arterial pressure (MAP) in the anesthetised rat. P. fucus venom exhibited a hypotensive response, while venom from G. tricuspidata displayed a single depressor response. All venoms induced cardiovascular collapse at 200 μg/kg, i.v. The in vitro neurotoxic effects of venom were examined using the chick biventer cervicis nerve-muscle (CBCNM) preparation. N. kuhlii, H. toshi, and P. fucus venoms caused concentration-dependent inhibition of indirect twitches in the CBCNM preparation. These three venoms also inhibited responses to exogenous acetylcholine (ACh) and carbachol (CCh), but not potassium chloride (KCl), indicating a post-synaptic mode of action. Venom from G. tricuspidata, M. cephalus, and D. tumifrons had no significant effect on indirect twitches or agonist responses in the CBCNM. Our results demonstrate that envenoming by these species of fish may result in moderate cardiovascular and/or neurotoxic effects. Future studies aimed at identifying the molecules responsible for these effects could uncover potentially novel lead compounds for future pharmaceuticals, in addition to generating new knowledge about the evolutionary relationships between venomous animals.
dc.languageEnglish
dc.publisherMDPI
dc.titleThe Cardiovascular and Neurotoxic Effects of the Venoms of Six Bony and Cartilaginous Fish Species
dc.typeJournal Article
dc.identifier.doi10.3390/toxins9020067
melbourne.affiliation.departmentPharmacology and Therapeutics
melbourne.source.titleToxins
melbourne.source.volume9
melbourne.source.issue2
dc.rights.licenseCC BY
melbourne.elementsid1190737
melbourne.contributor.authorJackson, Timothy
dc.identifier.eissn2072-6651
melbourne.accessrightsOpen Access


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