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dc.contributor.authorOostermeijer, S
dc.contributor.authorWhittle, S
dc.contributor.authorSuo, C
dc.contributor.authorAllen, NB
dc.contributor.authorSimmons, JG
dc.contributor.authorVijayakumar, N
dc.contributor.authorvan de Ven, PM
dc.contributor.authorJansen, LMC
dc.contributor.authorYucel, M
dc.contributor.authorPopma, A
dc.date.accessioned2020-12-18T02:51:48Z
dc.date.available2020-12-18T02:51:48Z
dc.date.issued2016-06-21
dc.identifierpii: tp2016111
dc.identifier.citationOostermeijer, S., Whittle, S., Suo, C., Allen, N. B., Simmons, J. G., Vijayakumar, N., van de Ven, P. M., Jansen, L. M. C., Yucel, M. & Popma, A. (2016). Trajectories of adolescent conduct problems in relation to cortical thickness development: a longitudinal MRI study. TRANSLATIONAL PSYCHIATRY, 6 (6), https://doi.org/10.1038/tp.2016.111.
dc.identifier.issn2158-3188
dc.identifier.urihttp://hdl.handle.net/11343/255529
dc.description.abstractMultiple cross-sectional imaging studies have identified structural abnormalities in prefrontal, temporal and limbic regions related to conduct problems (CPs). However, the relationship between development of such neurobiological deficits and developmental pathways of CPs has remained unclear. The current study investigated distinct trajectories of CP and related trajectories of cortical thickness within a community-based sample of adolescents (n=239), age range 12-19, to address this gap. Three trajectory classes were revealed using latent class growth analyses (LCGAs), comprising a 'desisting' CP group, an 'intermediate' CP group and a 'stable low' CP group. Structural magnetic resonance imaging (MRI) scans were collected with a subgroup of 171 adolescents at three waves throughout adolescence (ages 12, 16 and 19). Generalized estimating equation (GEE) analysis-comparing longitudinal changes in cortical thickness and subcortical volume between CP groups for several regions of interest (ROIs)-showed that these CP groups had differential trajectories of cortical thickness in the dorsolateral prefrontal cortex (dl-PFC), and the anterior cingulate cortex (ACC), and volume of the hippocampus. Adolescents in the desisting CP group showed an attenuation of the typical pattern of cortical thinning as present in the intermediate and stable low CP groups, in addition to an exaggeration of the typical pattern of hippocampal volume increase. These findings suggest that a deviant cortical thickness trajectory was related to a desisting CP pathway across adolescence. Such deviant neurodevelopmental growth trajectories may act as an underlying mechanism for developmental CP pathways, and possibly distinguish desisting antisocial adolescents.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleTrajectories of adolescent conduct problems in relation to cortical thickness development: a longitudinal MRI study
dc.typeJournal Article
dc.identifier.doi10.1038/tp.2016.111
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.departmentMelbourne School of Psychological Sciences
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleTranslational Psychiatry
melbourne.source.volume6
melbourne.source.issue6
melbourne.identifier.nhmrc350241
melbourne.identifier.nhmrc1007716
melbourne.identifier.nhmrc1021973
melbourne.identifier.arcDP1092637
melbourne.identifier.arcDP0878136
dc.rights.licenseCC BY
melbourne.elementsid1190968
melbourne.contributor.authorSimmons, Julian
melbourne.contributor.authorAllen, Nicholas
melbourne.contributor.authorYucel, Murat
melbourne.contributor.authorWhittle, Sarah
melbourne.contributor.authorOostermeijer, Sanne
dc.identifier.eissn2158-3188
melbourne.identifier.fundernameidNHMRC, 350241
melbourne.identifier.fundernameidNHMRC, 1007716
melbourne.identifier.fundernameidNHMRC, 1021973
melbourne.identifier.fundernameidAustralian Research Council, DP1092637
melbourne.identifier.fundernameidAustralian Research Council, DP0878136
melbourne.accessrightsOpen Access


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