Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
AuthorRogers, GB; Kozlowska, J; Keeble, J; Metcalfe, K; Fao, M; Dowd, SE; Mason, AJ; McGuckin, MA; Bruce, KD
Source TitleScientific Reports
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sMcGuckin, Michael
AffiliationMedicine Dentistry & Health Sciences
Document TypeJournal Article
CitationsRogers, G. B., Kozlowska, J., Keeble, J., Metcalfe, K., Fao, M., Dowd, S. E., Mason, A. J., McGuckin, M. A. & Bruce, K. D. (2014). Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice. SCIENTIFIC REPORTS, 4 (1), https://doi.org/10.1038/srep05437.
Access StatusOpen Access
Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.
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