Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

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    Author
    Rogers, GB; Kozlowska, J; Keeble, J; Metcalfe, K; Fao, M; Dowd, SE; Mason, AJ; McGuckin, MA; Bruce, KD
    Date
    2014-06-25
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    McGuckin, Michael
    Affiliation
    Medicine Dentistry & Health Sciences
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    Document Type
    Journal Article
    Citations
    Rogers, G. B., Kozlowska, J., Keeble, J., Metcalfe, K., Fao, M., Dowd, S. E., Mason, A. J., McGuckin, M. A. & Bruce, K. D. (2014). Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice. SCIENTIFIC REPORTS, 4 (1), https://doi.org/10.1038/srep05437.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255563
    DOI
    10.1038/srep05437
    Abstract
    Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

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