Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

    Thumbnail
    Download
    Citations
    Scopus
    Web of Science
    Altmetric
    37
    36
    Author
    Rogers, GB; Kozlowska, J; Keeble, J; Metcalfe, K; Fao, M; Dowd, SE; Mason, AJ; McGuckin, MA; Bruce, KD
    Date
    2014-06-25
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    McGuckin, Michael
    Affiliation
    Medicine Dentistry & Health Sciences
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Rogers, G. B., Kozlowska, J., Keeble, J., Metcalfe, K., Fao, M., Dowd, S. E., Mason, A. J., McGuckin, M. A. & Bruce, K. D. (2014). Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice. SCIENTIFIC REPORTS, 4 (1), https://doi.org/10.1038/srep05437.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255563
    DOI
    10.1038/srep05437
    Abstract
    Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

    Export Reference in RIS Format     

    Publisher licence
    CC BY-NC-ND
    Collections