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dc.contributor.authorZhan, Y
dc.contributor.authorCarrington, EM
dc.contributor.authorZhang, Y
dc.contributor.authorHeinzel, S
dc.contributor.authorLew, AM
dc.date.accessioned2020-12-18T02:59:13Z
dc.date.available2020-12-18T02:59:13Z
dc.date.issued2017-12-13
dc.identifier.citationZhan, Y., Carrington, E. M., Zhang, Y., Heinzel, S. & Lew, A. M. (2017). Life and Death of Activated T Cells: How Are They Different from Naive T Cells?. FRONTIERS IN IMMUNOLOGY, 8 (DEC), https://doi.org/10.3389/fimmu.2017.01809.
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/11343/255586
dc.description.abstractT cells are pivotal in immunity and immunopathology. After activation, T cells undergo a clonal expansion and differentiation followed by a contraction phase, once the pathogen has been cleared. Cell survival and cell death are critical for controlling the numbers of naïve T cells, effector, and memory T cells. While naïve T cell survival has been studied for a long time, more effort has gone into understanding the survival and death of activated T cells. Despite this effort, there is still much to be learnt about T cell survival, as T cells transition from naïve to effector to memory. One key advance is the development of inhibitors that may allow the temporal study of survival mechanisms operating in these distinct cell states. Naïve T cells were highly reliant on BCL-2 and sensitive to BCL-2 inhibition. Activated T cells are remarkably different in their regulation of apoptosis by pro- and antiapoptotic members of the BCL-2 family, rendering them differentially sensitive to antagonists blocking the function of one or more members of this family. Recent progress in understanding other programmed cell death mechanisms, especially necroptosis, suggests a unique role for alternative pathways in regulating death of activated T cells. Furthermore, we highlight a mechanism of epigenetic regulation of cell survival unique to activated T cells. Together, we present an update of our current understanding of the survival requirement of activated T cells.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleLife and Death of Activated T Cells: How Are They Different from Naive T Cells?
dc.typeJournal Article
dc.identifier.doi10.3389/fimmu.2017.01809
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleFrontiers in Immunology
melbourne.source.volume8
melbourne.source.issueDEC
dc.rights.licenseCC BY
melbourne.elementsid1286520
melbourne.contributor.authorZhan, Yifan
melbourne.contributor.authorCarrington, Emma
melbourne.contributor.authorHeinzel, Susanne
melbourne.contributor.authorLew, Andrew
dc.identifier.eissn1664-3224
melbourne.accessrightsOpen Access


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