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dc.contributor.authorLee, YC
dc.contributor.authorBressel, M
dc.contributor.authorGrant, P
dc.contributor.authorRussell, P
dc.contributor.authorSmith, C
dc.contributor.authorPicken, S
dc.contributor.authorCamm, S
dc.contributor.authorKiely, BE
dc.contributor.authorMilne, RL
dc.contributor.authorMcLachlan, SA
dc.contributor.authorHickey, M
dc.contributor.authorFriedlander, ML
dc.contributor.authorHopper, JL
dc.contributor.authorPhillips, KA
dc.date.accessioned2020-12-18T03:01:57Z
dc.date.available2020-12-18T03:01:57Z
dc.date.issued2017-10-01
dc.identifierpii: 10.1007/s10689-017-9977-x
dc.identifier.citationLee, Y. C., Bressel, M., Grant, P., Russell, P., Smith, C., Picken, S., Camm, S., Kiely, B. E., Milne, R. L., McLachlan, S. A., Hickey, M., Friedlander, M. L., Hopper, J. L. & Phillips, K. A. (2017). Improved quality of risk-reducing salpingo-oophorectomy in Australasian women at high risk of pelvic serous cancer. FAMILIAL CANCER, 16 (4), pp.461-469. https://doi.org/10.1007/s10689-017-9977-x.
dc.identifier.issn1389-9600
dc.identifier.urihttp://hdl.handle.net/11343/255600
dc.description.abstractOBJECTIVES: The quality of risk-reducing salpingo-oophorectomy (RRSO) performed in Australasian women was previously reported to be suboptimal. Here we describe the quality of RRSO performed since 2008 in women enrolled in the same cohort and determine whether it has improved. DESIGN: Prospective cohort study of women at high risk of pelvic serous cancer (PSC) in kConFab. Eligible women had RRSO between 2008 and 2014 and their RRSO surgical and pathology reports were reviewed. "Adequate" surgery and pathology were defined as complete removal and paraffin embedding of all ovarian and extra-uterine fallopian tube tissue, respectively. Associations between clinical factors and "adequate" pathology were assessed using logistic regression. Data were compared with published cohort data on RRSO performed prior to 2008 using Chi square test. RESULTS: Of 164 contemporary RRSOs performed in 78 centres, 158/159 (99%) had "adequate" surgery and 108/164 (66%) had "adequate" pathology. Surgery performed by a gynaecologic oncologist rather than a general gynaecologist [OR 8.2, 95%CI (3.6-20.4), p < 0.001], surgery without concurrent hysterectomy [OR 2.5, 95%CI (1.1-6.0), p = 0.03], more recent year of surgery [OR 1.4, 95%CI (1.1-1.8), p = 0.02], and clinical notation that indicated high risk [OR 19.4, 95%CI (3.1-385), p = 0.008] were independently associated with "adequate" pathology. Both surgery and pathology were significantly more likely to be "adequate" (p < 0.001) in this contemporary sample. CONCLUSION: The quality of RRSOs has significantly improved since our last report. Surgery by a gynaecologic oncologist who informs the pathologist that the woman is at high risk for PSC is associated with optimal RRSO pathology.
dc.languageEnglish
dc.publisherSPRINGER
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleImproved quality of risk-reducing salpingo-oophorectomy in Australasian women at high risk of pelvic serous cancer
dc.typeJournal Article
dc.identifier.doi10.1007/s10689-017-9977-x
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentObstetrics and Gynaecology
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFamilial Cancer
melbourne.source.volume16
melbourne.source.issue4
melbourne.source.pages461-469
dc.rights.licenseCC BY
melbourne.elementsid1191447
melbourne.contributor.authorPhillips, Kelly-Anne
melbourne.contributor.authorMilne, Roger
melbourne.contributor.authorHickey, Martha
melbourne.contributor.authorHopper, John
melbourne.contributor.authorMcLachlan, Sue-Anne
melbourne.contributor.authorGrant, Peter
melbourne.contributor.authorLee, Yeh
dc.identifier.eissn1573-7292
melbourne.accessrightsOpen Access


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