Show simple item record

dc.contributor.authorMaetschke, SR
dc.contributor.authorMadhamshettiwar, PB
dc.contributor.authorDavis, MJ
dc.contributor.authorRagan, MA
dc.date.accessioned2020-12-18T03:05:16Z
dc.date.available2020-12-18T03:05:16Z
dc.date.issued2014-03
dc.identifierpii: bbt034
dc.identifier.citationMaetschke, S. R., Madhamshettiwar, P. B., Davis, M. J. & Ragan, M. A. (2014). Supervised, semi-supervised and unsupervised inference of gene regulatory networks.. Brief Bioinform, 15 (2), pp.195-211. https://doi.org/10.1093/bib/bbt034.
dc.identifier.issn1467-5463
dc.identifier.urihttp://hdl.handle.net/11343/255624
dc.description.abstractInference of gene regulatory network from expression data is a challenging task. Many methods have been developed to this purpose but a comprehensive evaluation that covers unsupervised, semi-supervised and supervised methods, and provides guidelines for their practical application, is lacking. We performed an extensive evaluation of inference methods on simulated and experimental expression data. The results reveal low prediction accuracies for unsupervised techniques with the notable exception of the Z-SCORE method on knockout data. In all other cases, the supervised approach achieved the highest accuracies and even in a semi-supervised setting with small numbers of only positive samples, outperformed the unsupervised techniques.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSupervised, semi-supervised and unsupervised inference of gene regulatory networks.
dc.typeJournal Article
dc.identifier.doi10.1093/bib/bbt034
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleBriefings in Bioinformatics
melbourne.source.volume15
melbourne.source.issue2
melbourne.source.pages195-211
dc.rights.licenseCC BY
melbourne.elementsid1296441
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956069
melbourne.contributor.authorDavis, Melissa
dc.identifier.eissn1477-4054
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record