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dc.contributor.authorSaker, P
dc.contributor.authorFarrell, MJ
dc.contributor.authorEgan, GF
dc.contributor.authorMcKinley, MJ
dc.contributor.authorDenton, DA
dc.date.accessioned2020-12-18T03:06:40Z
dc.date.available2020-12-18T03:06:40Z
dc.date.issued2018-01-23
dc.identifierpii: 1717646115
dc.identifier.citationSaker, P., Farrell, M. J., Egan, G. F., McKinley, M. J. & Denton, D. A. (2018). Influence of anterior midcingulate cortex on drinking behavior during thirst and following satiation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115 (4), pp.786-791. https://doi.org/10.1073/pnas.1717646115.
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/11343/255633
dc.description.abstractIn humans, activity in the anterior midcingulate cortex (aMCC) is associated with both subjective thirst and swallowing. This region is therefore likely to play a prominent role in the regulation of drinking in response to dehydration. Using functional MRI, we investigated this possibility during a period of "drinking behavior" represented by a conjunction of preswallow and swallowing events. These events were examined in the context of a thirsty condition and an "oversated" condition, the latter induced by compliant ingestion of excess fluid. Brain regions associated with swallowing showed increased activity for drinking behavior in the thirsty condition relative to the oversated condition. These regions included the cingulate cortex, premotor areas, primary sensorimotor cortices, the parietal operculum, and the supplementary motor area. Psychophysical interaction analyses revealed increased functional connectivity between the same regions and the aMCC during drinking behavior in the thirsty condition. Functional connectivity during drinking behavior was also greater for the thirsty condition relative to the oversated condition between the aMCC and two subcortical regions, the cerebellum and the rostroventral medulla, the latter containing nuclei responsible for the swallowing reflex. Finally, during drinking behavior in the oversated condition, ratings of swallowing effort showed a negative association with functional connectivity between the aMCC and two cortical regions, the sensorimotor cortex and the supramarginal gyrus. The results of this study provide evidence that the aMCC helps facilitate swallowing during a state of thirst and is therefore likely to contribute to the regulation of drinking after dehydration.
dc.languageEnglish
dc.publisherNATL ACAD SCIENCES
dc.titleInfluence of anterior midcingulate cortex on drinking behavior during thirst and following satiation
dc.typeJournal Article
dc.identifier.doi10.1073/pnas.1717646115
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentPhysiology
melbourne.source.titleProceedings of the National Academy of Sciences of USA
melbourne.source.volume115
melbourne.source.issue4
melbourne.source.pages786-791
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1288631
melbourne.contributor.authorEgan, Gary
melbourne.contributor.authorFarrell, Michael
melbourne.contributor.authorDenton, Derek
melbourne.contributor.authorSaker, Pascal Dorian
melbourne.contributor.authorMcKinley, Michael
dc.identifier.eissn1091-6490
melbourne.accessrightsOpen Access


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