Criteria for Identifying Patients With Staphylococcus aureus Bacteremia Who Are at Low Risk of Endocarditis: A Systematic Review

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Author
Heriot, GS; Cronin, K; Tong, SYC; Cheng, AC; Liew, DDate
2017-09-01Source Title
Open Forum Infectious DiseasesPublisher
OXFORD UNIV PRESS INCAffiliation
Microbiology and ImmunologyDoherty Institute
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Journal ArticleCitations
Heriot, G. S., Cronin, K., Tong, S. Y. C., Cheng, A. C. & Liew, D. (2017). Criteria for Identifying Patients With Staphylococcus aureus Bacteremia Who Are at Low Risk of Endocarditis: A Systematic Review. OPEN FORUM INFECTIOUS DISEASES, 4 (4), https://doi.org/10.1093/ofid/ofx261.Access Status
Open AccessAbstract
This systematic review examines the methods and results of recent studies reporting clinical criteria able to identify patients with Staphylococcus aureus bacteremia who are at very low risk of endocarditis. We searched PubMed, EMBASE, and the Cochrane Collaboration CENTRAL database for articles published after March 1994 using a combination of MeSH and free text search terms for S. aureus AND bacteremia AND endocarditis. Studies were included if they presented a combination of clinical and microbiological criteria with a negative likelihood ratio of ≤0.20 for endocarditis. We found 8 studies employing various criteria and reference standards whose criteria were associated with negative likelihood ratios between 0.00 and 0.19 (corresponding to 0%-5% risk of endocarditis at 20% background prevalence). The benefit of echocardiography for patients fulfilling these criteria is uncertain.
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