Show simple item record

dc.contributor.authorCheng, Y
dc.contributor.authorHeasman, K
dc.contributor.authorPeck, S
dc.contributor.authorPeel, E
dc.contributor.authorGooley, RM
dc.contributor.authorPapenfuss, AT
dc.contributor.authorHogg, CJ
dc.contributor.authorBelov, K
dc.date.accessioned2020-12-18T03:10:37Z
dc.date.available2020-12-18T03:10:37Z
dc.date.issued2017-03-16
dc.identifierpii: srep44716
dc.identifier.citationCheng, Y., Heasman, K., Peck, S., Peel, E., Gooley, R. M., Papenfuss, A. T., Hogg, C. J. & Belov, K. (2017). Significant decline in anticancer immune capacity during puberty in the Tasmanian devil. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/srep44716.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/255662
dc.description.abstractTasmanian devils (Sarcophilus harrisii) are at risk of extinction in the wild due to Devil Facial Tumour Disease (DFTD), a rare contagious cancer. The prevalence of DFTD differs by age class: higher disease prevalence is seen in adults (2-3 years) versus younger devils (<2 years). Here we propose that immunological changes during puberty may play a role in susceptibility to DFTD. We show that the second year of life is a key developmental period for Tasmanian devils, during which they undergo puberty and pronounced changes in the immune system. Puberty coincides with a significant decrease in lymphocyte abundance resulting in a much higher neutrophil:lymphocyte ratio in adults than subadults. Quantitative PCR analysis of gene expression of transcription factors T-bet and GATA-3 and cytokines interferon gamma (IFN-γ) and interleukin 4 (IL-4) revealed a drastic increase in GATA-3 and IL-4 expression during puberty. These changes led to a significantly lower IFN-γ:IL-4 ratio in 2-year-olds than <1 year olds (on average 1.3-fold difference in males and 4.0-fold in females), which reflects a major shift of the immune system towards Th2 responses. These results all indicate that adult devils are expected to have a lower anticancer immune capacity than subadults, which may explain the observed pattern of disease prevalence of DFTD in the wild.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleSignificant decline in anticancer immune capacity during puberty in the Tasmanian devil
dc.typeJournal Article
dc.identifier.doi10.1038/srep44716
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1193196
melbourne.contributor.authorPapenfuss, Anthony
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record