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dc.contributor.authorHedlund, E
dc.contributor.authorBelnoue, L
dc.contributor.authorTheofilopoulos, S
dc.contributor.authorSalto, C
dc.contributor.authorBye, C
dc.contributor.authorParish, C
dc.contributor.authorDeng, Q
dc.contributor.authorKadkhodaei, B
dc.contributor.authorEricson, J
dc.contributor.authorArenas, E
dc.contributor.authorPerlmann, T
dc.contributor.authorSimon, A
dc.date.accessioned2020-12-18T03:10:46Z
dc.date.available2020-12-18T03:10:46Z
dc.date.issued2016-06-01
dc.identifierpii: srep26448
dc.identifier.citationHedlund, E., Belnoue, L., Theofilopoulos, S., Salto, C., Bye, C., Parish, C., Deng, Q., Kadkhodaei, B., Ericson, J., Arenas, E., Perlmann, T. & Simon, A. (2016). Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep26448.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/255663
dc.description.abstractDegeneration of dopamine neurons in the midbrain causes symptoms of the movement disorder, Parkinson disease. Dopamine neurons are generated from proliferating progenitor cells localized in the embryonic ventral midbrain. However, it remains unclear for how long cells with dopamine progenitor character are retained and if there is any potential for reactivation of such cells after cessation of normal dopamine neurogenesis. We show here that cells expressing Lmx1a and other progenitor markers remain in the midbrain aqueductal zone beyond the major dopamine neurogenic period. These cells express dopamine receptors, are located in regions heavily innervated by midbrain dopamine fibres and their proliferation can be stimulated by antagonizing dopamine receptors, ultimately leading to increased neurogenesis in vivo. Furthermore, treatment with dopamine receptor antagonists enhances neurogenesis in vitro, both from embryonic midbrain progenitors as well as from embryonic stem cells. Altogether our results indicate a potential for reactivation of resident midbrain cells with dopamine progenitor potential beyond the normal period of dopamine neurogenesis.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleDopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors
dc.typeJournal Article
dc.identifier.doi10.1038/srep26448
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleScientific Reports
melbourne.source.volume6
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1193405
melbourne.contributor.authorParish, Clare
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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