Dependence of cancer risk from environmental exposures on underlying genetic susceptibility: an illustration with polycyclic aromatic hydrocarbons and breast cancer
AuthorShen, J; Liao, Y; Hopper, JL; Goldberg, M; Santella, RM; Terry, MB
Source TitleBritish Journal of Cancer
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sHopper, John
AffiliationMelbourne School of Population and Global Health
Document TypeJournal Article
CitationsShen, J., Liao, Y., Hopper, J. L., Goldberg, M., Santella, R. M. & Terry, M. B. (2017). Dependence of cancer risk from environmental exposures on underlying genetic susceptibility: an illustration with polycyclic aromatic hydrocarbons and breast cancer. BRITISH JOURNAL OF CANCER, 116 (9), pp.1229-1233. https://doi.org/10.1038/bjc.2017.81.
Access StatusOpen Access
BACKGROUND: Most studies of environmental risk factors and breast cancer are conducted using average risk cohorts. METHODS: We examined the association between polycyclic aromatic hydrocarbon (PAH)-albumin adducts in bloods from baseline and breast cancer risk in a prospective nested case-control study (New York site of the BCFR, 80 cases and 156 controls). We estimated the 10-year absolute breast cancer risk by a risk model that uses pedigree information (BOADICEA) and evaluated whether the increased risk from PAH differed by absolute risk. RESULTS: Women with detectable levels of PAH had a twofold association with breast cancer risk (odds ratio (OR)=2.04; 95% CI=1.06-3.93) relative to women with non-detectable levels. The association increased with higher levels of PAH (⩾median) and by a higher level of absolute breast cancer risk (10-year risk ⩾3.4%: OR=4.09, 95% CI=1.38-12.13). CONCLUSIONS: These results support that family-based cohorts can be an efficient way to examine gene-environment interactions.
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