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    Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway

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    Author
    Huse, JT; Snuderl, M; Jones, DTW; Brathwaite, CD; Altman, N; Lavi, E; Saffery, R; Sexton-Oates, A; Blumcke, I; Capper, D; ...
    Date
    2017-03-01
    Source Title
    Acta Neuropathologica
    Publisher
    SPRINGER
    University of Melbourne Author/s
    Saffery, Richard; Sexton-Oates, Alexandra
    Affiliation
    Paediatrics (RCH)
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Huse, J. T., Snuderl, M., Jones, D. T. W., Brathwaite, C. D., Altman, N., Lavi, E., Saffery, R., Sexton-Oates, A., Blumcke, I., Capper, D., Karajannis, M. A., Benayed, R., Chavez, L., Thomas, C., Serrano, J., Borsu, L., Ladanyi, M. & Rosenblum, M. K. (2017). Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway. ACTA NEUROPATHOLOGICA, 133 (3), pp.417-429. https://doi.org/10.1007/s00401-016-1639-9.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255694
    DOI
    10.1007/s00401-016-1639-9
    Abstract
    Epileptogenic tumors affecting children and young adults are a morphologically diverse collection of neuroepithelial neoplasms that, as a group, exhibit varying levels of glial and/or neuronal differentiation. Recent advances in molecular profiling technology, including comprehensive DNA sequencing and methylation analysis, have enabled the application of more precise and biologically relevant classification schemes to these tumors. In this report, we describe a morphologically and molecularly distinct epileptogenic neoplasm, the polymorphous low-grade neuroepithelial tumor of the young (PLNTY), which likely accounts for a sizable portion of oligodendroglioma-like tumors affecting the pediatric population. Characteristic microscopic findings most notably include infiltrative growth, the invariable presence of oligodendroglioma-like cellular components, and intense immunolabeling for cluster of differentiation 34 (CD34). Moreover, integrative molecular profiling reveals a distinct DNA methylation signature for PLNTYs, along with frequent genetic abnormalities involving either B-Raf proto-oncogene (BRAF) or fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3). These findings suggest that PLNTY represents a distinct biological entity within the larger spectrum of pediatric, low-grade neuroepithelial tumors.

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