Purinergic mechanosensory transduction and visceral pain

Download
Author
Burnstock, GDate
2009-11-30Source Title
Molecular PainPublisher
SAGE PUBLICATIONS INCUniversity of Melbourne Author/s
Burnstock, GeoffreyAffiliation
Pharmacology and TherapeuticsMetadata
Show full item recordDocument Type
Journal ArticleCitations
Burnstock, G. (2009). Purinergic mechanosensory transduction and visceral pain. MOLECULAR PAIN, 5, https://doi.org/10.1186/1744-8069-5-69.Access Status
Open AccessAbstract
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain. Experimental evidence for this mechanism in urinary bladder, ureter, gut, lung, uterus, tooth-pulp and tongue is reviewed. Potential therapeutic strategies are considered for the treatment of visceral pain in such conditions as renal colic, interstitial cystitis and inflammatory bowel disease by agents that interfere with mechanosensory transduction in the organs considered, including P2X3 and P2X2/3 receptor antagonists that are orally bioavailable and stable in vivo and agents that inhibit or enhance ATP release and breakdown.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References