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dc.contributor.authorBinger, KJ
dc.contributor.authorCorte-Real, BF
dc.contributor.authorKleinewietfeld, M
dc.date.accessioned2020-12-18T03:16:22Z
dc.date.available2020-12-18T03:16:22Z
dc.date.issued2017-03-21
dc.identifier.citationBinger, K. J., Corte-Real, B. F. & Kleinewietfeld, M. (2017). Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity. FRONTIERS IN IMMUNOLOGY, 8 (MAR), https://doi.org/10.3389/fimmu.2017.00311.
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/11343/255700
dc.description.abstractInterleukin-17-producing T helper (Th17) cells are critical for the host defense of bacterial and fungal pathogens and also play a major role in driving pathogenic autoimmune responses. Recent studies have indicated that the generation of Th17 cells from naïve CD4+ T cells is coupled with massive cellular metabolic adaptations, necessary to cope with different energy and metabolite requirements associated with switching from a resting to proliferative state. Furthermore, Th17 cells have to secure these metabolic adaptations when facing nutrient-limiting environments, such as at the sites of inflammation. Accumulating data indicates that this metabolic reprogramming is significantly linked to the differentiation of T helper cells and, particularly, that the metabolic changes of Th17 cells and anti-inflammatory Forkhead box P3+ regulatory T cells are tightly and reciprocally regulated. Thus, a better understanding of these processes could offer potential new targets for therapeutic interventions for autoimmune diseases. In this mini-review, we will highlight some of the recent advances and discoveries in the field, with a particular focus on metabolic demands of Th17 cells and their implications for autoimmunity.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleImmunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity
dc.typeJournal Article
dc.identifier.doi10.3389/fimmu.2017.00311
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.source.titleFrontiers in Immunology
melbourne.source.volume8
melbourne.source.issueMAR
melbourne.identifier.nhmrc1037633
dc.rights.licenseCC BY
melbourne.elementsid1200294
melbourne.contributor.authorBinger, Katrina
dc.identifier.eissn1664-3224
melbourne.identifier.fundernameidNHMRC, 1037633
melbourne.accessrightsOpen Access


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