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dc.contributor.authorFlemmer, AW
dc.contributor.authorThio, M
dc.contributor.authorWallace, MJ
dc.contributor.authorLee, K
dc.contributor.authorKitchen, MJ
dc.contributor.authorKerr, L
dc.contributor.authorRoehr, CC
dc.contributor.authorFouras, A
dc.contributor.authorCarnibella, R
dc.contributor.authorJani, JC
dc.contributor.authorDeKoninck, P
dc.contributor.authorte Pas, AB
dc.contributor.authorPearson, JT
dc.contributor.authorHooper, SB
dc.date.accessioned2020-12-18T03:16:47Z
dc.date.available2020-12-18T03:16:47Z
dc.date.issued2017-09-01
dc.identifierpii: pr201791
dc.identifier.citationFlemmer, A. W., Thio, M., Wallace, M. J., Lee, K., Kitchen, M. J., Kerr, L., Roehr, C. C., Fouras, A., Carnibella, R., Jani, J. C., DeKoninck, P., te Pas, A. B., Pearson, J. T. & Hooper, S. B. (2017). Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion. PEDIATRIC RESEARCH, 82 (3), pp.536-543. https://doi.org/10.1038/pr.2017.91.
dc.identifier.issn0031-3998
dc.identifier.urihttp://hdl.handle.net/11343/255703
dc.description.abstractBackgroundA congenital diaphragmatic hernia (DH) can result in severe lung hypoplasia that increases the risk of morbidity and mortality after birth; however, little is known about the cardiorespiratory transition at birth.MethodsUsing phase-contrast X-ray imaging and angiography, we examined the cardiorespiratory transition at birth in rabbit kittens with DHs. Surgery was performed on pregnant New Zealand white rabbits (n=18) at 25 days' gestation to induce a left-sided DH. Kittens were delivered at 30 days' gestation, intubated, and ventilated to achieve a tidal volume (Vt) of 8 ml/kg in control and 4 ml/kg in DH kittens while they were imaged.ResultsFunctional residual capacity (FRC) recruitment and Vt in the hypoplastic left lung were markedly reduced, resulting in a disproportionate distribution of FRC into the right lung. Following lung aeration, relative pulmonary blood flow (PBF) increased equally in both lungs, and the increase in pulmonary venous return was similar in both control and DH kittens.ConclusionThese findings indicate that nonuniform lung hypoplasia caused by DH alters the distribution of ventilation away from hypoplastic and into normally grown lung regions. During transition, the increase in PBF and pulmonary venous return, which is vital for maintaining cardiac output, is not affected by lung hypoplasia.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleLung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion
dc.typeJournal Article
dc.identifier.doi10.1038/pr.2017.91
melbourne.affiliation.departmentObstetrics and Gynaecology
melbourne.source.titlePediatric Research
melbourne.source.volume82
melbourne.source.issue3
melbourne.source.pages536-543
dc.rights.licenseCC BY
melbourne.elementsid1200775
melbourne.contributor.authorThio, Marta
dc.identifier.eissn1530-0447
melbourne.accessrightsOpen Access


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