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dc.contributor.authorRodriguez, AJ
dc.contributor.authorMousa, A
dc.contributor.authorEbeling, PR
dc.contributor.authorScott, D
dc.contributor.authorde Courten, B
dc.date.accessioned2020-12-18T03:20:14Z
dc.date.available2020-12-18T03:20:14Z
dc.date.issued2018-01-18
dc.identifierpii: 10.1038/s41598-018-19708-0
dc.identifier.citationRodriguez, A. J., Mousa, A., Ebeling, P. R., Scott, D. & de Courten, B. (2018). Effects of vitamin D supplementation on inflammatory markers in heart failure: a systematic review and meta-analysis of randomized controlled trials. SCIENTIFIC REPORTS, 8 (1), https://doi.org/10.1038/s41598-018-19708-0.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/255726
dc.description.abstractVitamin D is reported to have anti-inflammatory properties; however the effects of vitamin D supplementation on inflammation in patients with heart failure (HF) have not been established. We performed a systematic review and meta-analysis examining effects of vitamin D supplementation on inflammatory markers in patients with HF. MEDLINE, CINAHL, EMBASE, All EBM, and Clinical Trials registries were systematically searched for RCTs from inception to 25 January 2017. Two independent reviewers screened all full text articles (no date or language limits) for RCTs reporting effects of vitamin D supplementation (any form, route, duration, and co-supplementation) compared with placebo or usual care on inflammatory markers in patients with heart failure. Two reviewers assessed risk of bias and quality using the grading of recommendations, assessment, development, and evaluation approach. Seven studies met inclusion criteria and six had data available for pooling (n = 1012). In meta-analyses, vitamin D-supplemented groups had lower concentrations of tumor necrosis factor-alpha (TNF-α) at follow-up compared with controls (n = 380; p = 0.04). There were no differences in C-reactive protein (n = 231), interleukin (IL)-10 (n = 247) or IL-6 (n = 154) between vitamin D and control groups (all p > 0.05). Our findings suggest that vitamin D supplementation may have specific, but modest effects on inflammatory markers in HF.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEffects of vitamin D supplementation on inflammatory markers in heart failure: a systematic review and meta-analysis of randomized controlled trials
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-018-19708-0
melbourne.affiliation.departmentMedicine, Western Health
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Reports
melbourne.source.volume8
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1298132
melbourne.contributor.authorScott, David
melbourne.contributor.authorEbeling, Peter
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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