University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Paediatrics (RCH)
  • Paediatrics (RCH) - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Paediatrics (RCH)
  • Paediatrics (RCH) - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants

    Thumbnail
    Download
    Published version (2.822Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    24
    22
    Author
    Ryan, D; Sutherland, MR; Flores, TJ; Kent, AL; Dahlstrom, JE; Puelles, VG; Bertram, JF; McMahon, AP; Little, MH; Moore, L; ...
    Date
    2018-01-01
    Source Title
    EBioMedicine
    Publisher
    ELSEVIER SCIENCE BV
    University of Melbourne Author/s
    Little, Melissa
    Affiliation
    Paediatrics (RCH)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Ryan, D., Sutherland, M. R., Flores, T. J., Kent, A. L., Dahlstrom, J. E., Puelles, V. G., Bertram, J. F., McMahon, A. P., Little, M. H., Moore, L. & Black, M. J. (2018). Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants. EBIOMEDICINE, 27, pp.275-283. https://doi.org/10.1016/j.ebiom.2017.12.016.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255742
    DOI
    10.1016/j.ebiom.2017.12.016
    Abstract
    BACKGROUND: During normal human kidney development, nephrogenesis (the formation of nephrons) is complete by term birth, with the majority of nephrons formed late in gestation. The aim of this study was to morphologically examine nephrogenesis in fetal human kidneys from 20 to 41weeks of gestation. METHODS: Kidney samples were obtained at autopsy from 71 infants that died acutely in utero or within 24h after birth. Using image analysis, nephrogenic zone width, the number of glomerular generations, renal corpuscle cross-sectional area and the cellular composition of glomeruli were examined. Kidneys from female and male infants were analysed separately. FINDINGS: The number of glomerular generations formed within the fetal kidneys was directly proportional to gestational age, body weight and kidney weight, with variability between individuals in the ultimate number of generations (8 to 12) and in the timing of the cessation of nephrogenesis (still ongoing at 37weeks gestation in one infant). There was a slight but significant (r2=0.30, P=0.001) increase in renal corpuscle cross-sectional area from mid gestation to term in females, but this was not evident in males. The proportions of podocytes, endothelial and non-epithelial cells within mature glomeruli were stable throughout gestation. INTERPRETATION: These findings highlight spatial and temporal variability in nephrogenesis in the developing human kidney, whereas the relative cellular composition of glomeruli does not appear to be influenced by gestational age.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Paediatrics (RCH) - Research Publications [1852]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors