Show simple item record

dc.contributor.authorChan, LWM
dc.contributor.authorImanishi, J
dc.contributor.authorGrinsell, DG
dc.contributor.authorChoong, P
dc.date.accessioned2020-12-18T03:23:29Z
dc.date.available2020-12-18T03:23:29Z
dc.date.issued2018-01-22
dc.identifier.citationChan, L. W. M., Imanishi, J., Grinsell, D. G. & Choong, P. (2018). Preoperative Radiotherapy and Wide Resection for Soft Tissue Sarcomas: Achieving a Low Rate of Major Wound Complications with the Use of Flaps. Results of a Single Surgical Team. FRONTIERS IN SURGERY, 4, https://doi.org/10.3389/fsurg.2017.00079.
dc.identifier.issn2296-875X
dc.identifier.urihttp://hdl.handle.net/11343/255748
dc.description.abstractBackground: Surgery in combination with radiotherapy (RT) has become the standard of care for most soft tissue sarcomas. The choice between pre- and postoperative RT is controversial. Preoperative RT is associated with a 32-35% rate of major wound complications (MWC) and 16-25% rate of reoperation. The role of vascularized soft tissue "flaps" in reducing complications is unclear. We report the outcomes of patients treated with preoperative RT, resection, and flap reconstruction. Patients and methods: 122 treatment episodes involving 117 patients were retrospectively reviewed. All patients were treated with 50.4 Gy of external beam radiation. Surgery was performed at 4-8 weeks after completion of RT by the same combination of orthopedic oncology and plastic reconstructive surgeon. Defects were reconstructed with 64 free and 59 pedicled/local flaps. Results: 30 (25%) patients experienced a MWC and 17 (14%) required further surgery. 20% of complications were exclusively related to the donor site. There was complete or partial loss of three flaps. There was no difference in the rate of MWC or reoperation for complications with respect to age, sex, tumor site, previous unplanned excision, tumor grade, depth, and type of flap. Tumor size ≥8 cm was associated with a higher rate of reoperation (11/44 vs 6/78; P = 0.008) but the rate of MWC was not significant (16/44 vs 14/78; P = 0.066). Conclusion: The use of soft tissue flaps is associated with a low rate of MWC and reoperation. Our results suggest that a high rate of flap usage may be required to observe a reduction in complication rates.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.titlePreoperative Radiotherapy and Wide Resection for Soft Tissue Sarcomas: Achieving a Low Rate of Major Wound Complications with the Use of Flaps. Results of a Single Surgical Team
dc.typeJournal Article
dc.identifier.doi10.3389/fsurg.2017.00079
melbourne.affiliation.departmentSurgery (St Vincent's)
melbourne.source.titleFrontiers in Surgery
melbourne.source.volume4
dc.rights.licenseCC BY
melbourne.elementsid1304806
melbourne.contributor.authorChoong, Peter
dc.identifier.eissn2296-875X
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record