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    Characterization of 19A-like 19F pneumococcal isolates from Papua New Guinea and Fiji.

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    Author
    Dunne, EM; Tikkanen, L; Balloch, A; Gould, K; Yoannes, M; Phuanukoonnon, S; Licciardi, PV; Russell, FM; Mulholland, EK; Satzke, C; ...
    Date
    2015-09
    Source Title
    New Microbes and New Infections
    Publisher
    Elsevier BV
    University of Melbourne Author/s
    Satzke, Catherine; Russell, Fiona; Mulholland, Edward
    Affiliation
    Paediatrics (RCH)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Dunne, E. M., Tikkanen, L., Balloch, A., Gould, K., Yoannes, M., Phuanukoonnon, S., Licciardi, P. V., Russell, F. M., Mulholland, E. K., Satzke, C. & Hinds, J. (2015). Characterization of 19A-like 19F pneumococcal isolates from Papua New Guinea and Fiji.. New Microbes New Infect, 7, pp.86-88. https://doi.org/10.1016/j.nmni.2015.06.008.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255757
    DOI
    10.1016/j.nmni.2015.06.008
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547413
    Abstract
    Molecular identification of Streptococcus pneumoniae serotype 19F is routinely performed by PCR targeting the wzy gene of the capsular biosynthetic locus. However, 19F isolates with genetic similarity to 19A have been reported in the United States and Brazil. We screened 78 pneumococcal carriage isolates and found six 19F wzy variants that originated from children in Papua New Guinea and Fiji. Isolates were characterized using multilocus sequence typing and opsonophagocytic assays. The 19F wzy variants displayed similar susceptibility to anti-19F IgG antibodies compared to standard 19F isolates. Our findings indicate that these 19F variants may be more common than previously believed.

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