University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Affiliates
  • Bio21
  • Bio21 - Research Publications
  • View Item
  • Minerva Access
  • Affiliates
  • Bio21
  • Bio21 - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation

    Thumbnail
    Download
    Published version (4.566Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    98
    91
    Author
    Pearson, C; Thornton, EE; McKenzie, B; Schaupp, A-L; Huskens, N; Griseri, T; West, N; Tung, S; Seddon, BP; Uhlig, HH; ...
    Date
    2016-01-18
    Source Title
    eLife
    Publisher
    ELIFE SCIENCES PUBLICATIONS LTD
    University of Melbourne Author/s
    McKenzie, Brent
    Affiliation
    Bio21
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Pearson, C., Thornton, E. E., McKenzie, B., Schaupp, A. -L., Huskens, N., Griseri, T., West, N., Tung, S., Seddon, B. P., Uhlig, H. H. & Powrie, F. (2016). ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation. ELIFE, 5 (JANUARY2016), https://doi.org/10.7554/eLife.10066.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255762
    DOI
    10.7554/eLife.10066
    Abstract
    Innate lymphoid cells (ILCs) contribute to host defence and tissue repair but can induce immunopathology. Recent work has revealed tissue-specific roles for ILCs; however, the question of how a small population has large effects on immune homeostasis remains unclear. We identify two mechanisms that ILC3s utilise to exert their effects within intestinal tissue. ILC-driven colitis depends on production of granulocyte macrophage-colony stimulating factor (GM-CSF), which recruits and maintains intestinal inflammatory monocytes. ILCs present in the intestine also enter and exit cryptopatches in a highly dynamic process. During colitis, ILC3s mobilize from cryptopatches, a process that can be inhibited by blocking GM-CSF, and mobilization precedes inflammatory foci elsewhere in the tissue. Together these data identify the IL-23R/GM-CSF axis within ILC3 as a key control point in the accumulation of innate effector cells in the intestine and in the spatio-temporal dynamics of ILCs in the intestinal inflammatory response.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Bio21 - Research Publications [232]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors