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    Pre-diagnosis diet and survival after a diagnosis of ovarian cancer

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    12
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    Author
    Playdon, MC; Nagle, CM; Ibiebele, TI; Ferrucci, LM; Protani, MM; Carter, J; Hyde, SE; Neesham, D; Nicklin, JL; Mayne, ST; ...
    Date
    2017-06-06
    Source Title
    British Journal of Cancer
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Neesham, Deborah
    Affiliation
    Obstetrics and Gynaecology
    Metadata
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    Document Type
    Journal Article
    Citations
    Playdon, M. C., Nagle, C. M., Ibiebele, T. I., Ferrucci, L. M., Protani, M. M., Carter, J., Hyde, S. E., Neesham, D., Nicklin, J. L., Mayne, S. T. & Webb, P. M. (2017). Pre-diagnosis diet and survival after a diagnosis of ovarian cancer. BRITISH JOURNAL OF CANCER, 116 (12), pp.1627-1637. https://doi.org/10.1038/bjc.2017.120.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255765
    DOI
    10.1038/bjc.2017.120
    Abstract
    BACKGROUND: The relationship between diet and survival after ovarian cancer diagnosis is unclear as a result of a limited number of studies and inconsistent findings. METHODS: We examined the association between pre-diagnostic diet and overall survival in a population-based cohort (n=811) of Australian women diagnosed with invasive epithelial ovarian cancer between 2002 and 2005. Diet was measured by validated food frequency questionnaire. Deaths were ascertained up to 31 August 2014 via medical record review and Australian National Death Index linkage. We conducted Cox proportional hazards regression analysis, controlling for diagnosis age, tumour stage, grade and subtype, residual disease, smoking status, body mass index, physical activity, marital status, and energy intake. RESULTS: We observed improved survival with highest compared with lowest quartile of fibre intake (hazard ratio (HR)=0.69, 95% CI: 0.53-0.90, P-trend=0.002). There was a suggestion of better survival for women with highest compared with lowest intake category of green leafy vegetables (HR=0.79, 95% CI: 0.62-0.99), fish (HR=0.74, 95% CI: 0.57-0.95), poly- to mono-unsaturated fat ratio (HR=0.76, 95% CI: 0.59-0.98), and worse survival with higher glycaemic index (HR=1.28, 95% CI: 1.01-1.65, P-trend=0.03). CONCLUSIONS: The associations we observed between healthy components of diet pre-diagnosis and ovarian cancer survival raise the possibility that dietary choices after diagnosis may improve survival.

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