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dc.contributor.authorPlaydon, MC
dc.contributor.authorNagle, CM
dc.contributor.authorIbiebele, TI
dc.contributor.authorFerrucci, LM
dc.contributor.authorProtani, MM
dc.contributor.authorCarter, J
dc.contributor.authorHyde, SE
dc.contributor.authorNeesham, D
dc.contributor.authorNicklin, JL
dc.contributor.authorMayne, ST
dc.contributor.authorWebb, PM
dc.date.accessioned2020-12-18T03:25:48Z
dc.date.available2020-12-18T03:25:48Z
dc.date.issued2017-06-06
dc.identifierpii: bjc2017120
dc.identifier.citationPlaydon, M. C., Nagle, C. M., Ibiebele, T. I., Ferrucci, L. M., Protani, M. M., Carter, J., Hyde, S. E., Neesham, D., Nicklin, J. L., Mayne, S. T. & Webb, P. M. (2017). Pre-diagnosis diet and survival after a diagnosis of ovarian cancer. BRITISH JOURNAL OF CANCER, 116 (12), pp.1627-1637. https://doi.org/10.1038/bjc.2017.120.
dc.identifier.issn0007-0920
dc.identifier.urihttp://hdl.handle.net/11343/255765
dc.description.abstractBACKGROUND: The relationship between diet and survival after ovarian cancer diagnosis is unclear as a result of a limited number of studies and inconsistent findings. METHODS: We examined the association between pre-diagnostic diet and overall survival in a population-based cohort (n=811) of Australian women diagnosed with invasive epithelial ovarian cancer between 2002 and 2005. Diet was measured by validated food frequency questionnaire. Deaths were ascertained up to 31 August 2014 via medical record review and Australian National Death Index linkage. We conducted Cox proportional hazards regression analysis, controlling for diagnosis age, tumour stage, grade and subtype, residual disease, smoking status, body mass index, physical activity, marital status, and energy intake. RESULTS: We observed improved survival with highest compared with lowest quartile of fibre intake (hazard ratio (HR)=0.69, 95% CI: 0.53-0.90, P-trend=0.002). There was a suggestion of better survival for women with highest compared with lowest intake category of green leafy vegetables (HR=0.79, 95% CI: 0.62-0.99), fish (HR=0.74, 95% CI: 0.57-0.95), poly- to mono-unsaturated fat ratio (HR=0.76, 95% CI: 0.59-0.98), and worse survival with higher glycaemic index (HR=1.28, 95% CI: 1.01-1.65, P-trend=0.03). CONCLUSIONS: The associations we observed between healthy components of diet pre-diagnosis and ovarian cancer survival raise the possibility that dietary choices after diagnosis may improve survival.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titlePre-diagnosis diet and survival after a diagnosis of ovarian cancer
dc.typeJournal Article
dc.identifier.doi10.1038/bjc.2017.120
melbourne.affiliation.departmentObstetrics and Gynaecology
melbourne.source.titleBritish Journal of Cancer
melbourne.source.volume116
melbourne.source.issue12
melbourne.source.pages1627-1637
melbourne.identifier.nhmrc400281
melbourne.identifier.nhmrc400413
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1205753
melbourne.contributor.authorNeesham, Deborah
dc.identifier.eissn1532-1827
melbourne.identifier.fundernameidNHMRC, 400281
melbourne.identifier.fundernameidNHMRC, 400413
melbourne.accessrightsOpen Access


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