University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Affiliates
  • Bio21
  • Bio21 - Research Publications
  • View Item
  • Minerva Access
  • Affiliates
  • Bio21
  • Bio21 - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

    Thumbnail
    Download
    Published version (1.766Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    67
    60
    Author
    Mason, RR; Mokhtar, R; Matzaris, M; Selathurai, A; Kowalski, GM; Mokbel, N; Meikle, PJ; Bruce, CR; Watt, MJ
    Date
    2014-09-01
    Source Title
    Molecular Metabolism
    Publisher
    ELSEVIER
    University of Melbourne Author/s
    Meikle, Peter; Watt, Matthew
    Affiliation
    Bio21
    Physiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Mason, R. R., Mokhtar, R., Matzaris, M., Selathurai, A., Kowalski, G. M., Mokbel, N., Meikle, P. J., Bruce, C. R. & Watt, M. J. (2014). PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle. MOLECULAR METABOLISM, 3 (6), pp.652-663. https://doi.org/10.1016/j.molmet.2014.06.002.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255782
    DOI
    10.1016/j.molmet.2014.06.002
    Abstract
    Defective control of lipid metabolism leading to lipotoxicity causes insulin resistance in skeletal muscle, a major factor leading to diabetes. Here, we demonstrate that perilipin (PLIN) 5 is required to couple intramyocellular triacylglycerol lipolysis with the metabolic demand for fatty acids. PLIN5 ablation depleted triacylglycerol stores but increased sphingolipids including ceramide, hydroxylceramides and sphingomyelin. We generated perilipin 5 (Plin5)(-/-) mice to determine the functional significance of PLIN5 in metabolic control and insulin action. Loss of PLIN5 had no effect on body weight, feeding or adiposity but increased whole-body carbohydrate oxidation. Plin5 (-/-) mice developed skeletal muscle insulin resistance, which was associated with ceramide accumulation. Liver insulin sensitivity was improved in Plin5 (-/-) mice, indicating tissue-specific effects of PLIN5 on insulin action. We conclude that PLIN5 plays a critical role in coordinating skeletal muscle triacylglycerol metabolism, which impacts sphingolipid metabolism, and is requisite for the maintenance of skeletal muscle insulin action.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Physiology - Research Publications [361]
    • Bio21 - Research Publications [232]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors