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dc.contributor.authorWang, Q
dc.contributor.authorHolmes, WR
dc.contributor.authorSosnik, J
dc.contributor.authorSchilling, T
dc.contributor.authorNie, Q
dc.date.accessioned2020-12-18T03:28:28Z
dc.date.available2020-12-18T03:28:28Z
dc.date.issued2017-01
dc.identifierpii: PCOMPBIOL-D-16-01455
dc.identifier.citationWang, Q., Holmes, W. R., Sosnik, J., Schilling, T. & Nie, Q. (2017). Cell Sorting and Noise-Induced Cell Plasticity Coordinate to Sharpen Boundaries between Gene Expression Domains.. PLoS Comput Biol, 13 (1), pp.e1005307-. https://doi.org/10.1371/journal.pcbi.1005307.
dc.identifier.issn1553-734X
dc.identifier.urihttp://hdl.handle.net/11343/255785
dc.description.abstractA fundamental question in biology is how sharp boundaries of gene expression form precisely in spite of biological variation/noise. Numerous mechanisms position gene expression domains across fields of cells (e.g. morphogens), but how these domains are refined remains unclear. In some cases, domain boundaries sharpen through differential adhesion-mediated cell sorting. However, boundaries can also sharpen through cellular plasticity, with cell fate changes driven by up- or down-regulation of gene expression. In this context, we have argued that noise in gene expression can help cells transition to the correct fate. Here we investigate the efficacy of cell sorting, gene expression plasticity, and their combination in boundary sharpening using multi-scale, stochastic models. We focus on the formation of hindbrain segments (rhombomeres) in the developing zebrafish as an example, but the mechanisms investigated apply broadly to many tissues. Our results indicate that neither sorting nor plasticity is sufficient on its own to sharpen transition regions between different rhombomeres. Rather the two have complementary strengths and weaknesses, which synergize when combined to sharpen gene expression boundaries.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCell Sorting and Noise-Induced Cell Plasticity Coordinate to Sharpen Boundaries between Gene Expression Domains.
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pcbi.1005307
melbourne.affiliation.departmentSchool of Mathematics and Statistics
melbourne.source.titlePLoS Computational Biology
melbourne.source.volume13
melbourne.source.issue1
melbourne.source.pagese1005307-
dc.rights.licenseCC BY
melbourne.elementsid1208422
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279720
melbourne.contributor.authorHOLMES, WILLIAM
dc.identifier.eissn1553-7358
melbourne.accessrightsOpen Access


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