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dc.contributor.authorHui, K
dc.contributor.authorNalder, M
dc.contributor.authorBuising, K
dc.contributor.authorPefanis, A
dc.contributor.authorOoi, KY
dc.contributor.authorPedagogos, E
dc.contributor.authorNelson, C
dc.contributor.authorKirkpatrick, CMJ
dc.contributor.authorKong, DCM
dc.date.accessioned2020-12-18T03:28:50Z
dc.date.available2020-12-18T03:28:50Z
dc.date.issued2017-05-12
dc.identifierpii: 10.1186/s12882-017-0575-9
dc.identifier.citationHui, K., Nalder, M., Buising, K., Pefanis, A., Ooi, K. Y., Pedagogos, E., Nelson, C., Kirkpatrick, C. M. J. & Kong, D. C. M. (2017). Patterns of use and appropriateness of antibiotics prescribed to patients receiving haemodialysis: an observational study. BMC NEPHROLOGY, 18 (1), https://doi.org/10.1186/s12882-017-0575-9.
dc.identifier.issn1471-2369
dc.identifier.urihttp://hdl.handle.net/11343/255788
dc.description.abstractBACKGROUND: There are limited published data on the types and appropriateness of oral and intravenous (IV) antibiotics prescribed to patients receiving haemodialysis. This information is critical to optimise antibiotic prescribing. Therefore this study aims to describe the patterns of use and the appropriateness of oral and IV antibiotics prescribed to patients receiving haemodialysis. METHODS: This was a prospective, observational study across four community and two hospital inpatient haemodialysis units in Melbourne, Australia. Data were collected from July 2014 to January 2015 from participants. Antibiotic regimens prescribed were compared with nationally available antibiotic guidelines and then classified as being either appropriate, inappropriate or not assessable by an expert multidisciplinary team using the National Antimicrobial Prescribing Survey tool. RESULTS: Overall, 114 participants consented to this study where 55.3% (63/114) received antibiotics and 235 antibiotic regimens were prescribed at a rate of 69.1 antibiotic regimens/100 patient-months. The most common oral antibiotics prescribed were amoxycillin/clavulanic acid and cephalexin. The most common IV antibiotics prescribed were vancomycin, piperacillin/tazobactam, cephazolin and ceftriaxone. The percentage of inappropriate antibiotic regimens prescribed were 34.9% (15/43) in the community setting and 22.1% (40/181) in the hospital setting. Furthermore, 29.4% (30/102) of oral and 20.5% (25/122) of IV antibiotic regimens were inappropriate with incorrect dosing as the primary reason. CONCLUSION: Although this study is limited by the sample size, it describes the high antibiotic exposure that patients receiving haemodialysis experience. Of concern is inappropriate dose and frequency being a major issue. This requires interventions focused on the quality use of medicines and antimicrobial stewardship aspects of prescribing in this population.
dc.languageEnglish
dc.publisherBIOMED CENTRAL LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titlePatterns of use and appropriateness of antibiotics prescribed to patients receiving haemodialysis: an observational study
dc.typeJournal Article
dc.identifier.doi10.1186/s12882-017-0575-9
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.departmentInfectious Diseases
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleBMC Nephrology
melbourne.source.volume18
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1208817
melbourne.contributor.authorBuising, Kirsty
melbourne.contributor.authorPedagogos, Eugenia
dc.identifier.eissn1471-2369
melbourne.accessrightsOpen Access


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