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    Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

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    Author
    Aldape, K; Amin, SB; Ashley, DM; Barnholtz-Sloan, JS; Bates, AJ; Beroukhim, R; Bock, C; Brat, DJ; Claus, EB; Costello, JF; ...
    Date
    2018-07-01
    Source Title
    Neuro-Oncology
    Publisher
    OXFORD UNIV PRESS INC
    University of Melbourne Author/s
    Grimmond, Sean; Gan, Hui
    Affiliation
    Medicine and Radiology
    Centre for Cancer Research
    Metadata
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    Document Type
    Journal Article
    Citations
    Aldape, K., Amin, S. B., Ashley, D. M., Barnholtz-Sloan, J. S., Bates, A. J., Beroukhim, R., Bock, C., Brat, D. J., Claus, E. B., Costello, J. F., de Groot, J. F., Finocchiaro, G., French, P. J., Gan, H. K., Griffith, B., Herold-Mende, C. C., Horbinski, C., Iavarone, A., Kalkanis, S. N. ,... Stead, L. (2018). Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium. NEURO-ONCOLOGY, 20 (7), pp.873-884. https://doi.org/10.1093/neuonc/noy020.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255805
    DOI
    10.1093/neuonc/noy020
    Abstract
    Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need.

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