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dc.contributor.authorAldape, K
dc.contributor.authorAmin, SB
dc.contributor.authorAshley, DM
dc.contributor.authorBarnholtz-Sloan, JS
dc.contributor.authorBates, AJ
dc.contributor.authorBeroukhim, R
dc.contributor.authorBock, C
dc.contributor.authorBrat, DJ
dc.contributor.authorClaus, EB
dc.contributor.authorCostello, JF
dc.contributor.authorde Groot, JF
dc.contributor.authorFinocchiaro, G
dc.contributor.authorFrench, PJ
dc.contributor.authorGan, HK
dc.contributor.authorGriffith, B
dc.contributor.authorHerold-Mende, CC
dc.contributor.authorHorbinski, C
dc.contributor.authorIavarone, A
dc.contributor.authorKalkanis, SN
dc.contributor.authorKarabatsou, K
dc.contributor.authorKim, H
dc.contributor.authorKouwenhoven, MCM
dc.contributor.authorMcDonald, KL
dc.contributor.authorMiletic, H
dc.contributor.authorNam, D-H
dc.contributor.authorNg, HK
dc.contributor.authorNiclou, SP
dc.contributor.authorNoushmehr, H
dc.contributor.authorOrmond, DR
dc.contributor.authorPoisson, LM
dc.contributor.authorReifenberger, G
dc.contributor.authorRoncaroli, F
dc.contributor.authorSa, JK
dc.contributor.authorSmitt, PAES
dc.contributor.authorSmits, M
dc.contributor.authorSouza, CF
dc.contributor.authorTabatabai, G
dc.contributor.authorVan Meir, EG
dc.contributor.authorVerhaak, RGW
dc.contributor.authorWatts, C
dc.contributor.authorWesseling, P
dc.contributor.authorWoehrer, A
dc.contributor.authorYung, WKA
dc.contributor.authorJungk, C
dc.contributor.authorHau, A-C
dc.contributor.authorvan Dyck, E
dc.contributor.authorWesterman, BA
dc.contributor.authorYin, J
dc.contributor.authorAbiola, O
dc.contributor.authorZeps, N
dc.contributor.authorGrimmond, S
dc.contributor.authorBuckland, M
dc.contributor.authorKhasraw, M
dc.contributor.authorSulman, EP
dc.contributor.authorMuscat, AM
dc.contributor.authorStead, L
dc.date.accessioned2020-12-18T03:31:33Z
dc.date.available2020-12-18T03:31:33Z
dc.date.issued2018-07-01
dc.identifierpii: 4843984
dc.identifier.citationAldape, K., Amin, S. B., Ashley, D. M., Barnholtz-Sloan, J. S., Bates, A. J., Beroukhim, R., Bock, C., Brat, D. J., Claus, E. B., Costello, J. F., de Groot, J. F., Finocchiaro, G., French, P. J., Gan, H. K., Griffith, B., Herold-Mende, C. C., Horbinski, C., Iavarone, A., Kalkanis, S. N. ,... Stead, L. (2018). Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium. NEURO-ONCOLOGY, 20 (7), pp.873-884. https://doi.org/10.1093/neuonc/noy020.
dc.identifier.issn1522-8517
dc.identifier.urihttp://hdl.handle.net/11343/255805
dc.description.abstractAdult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.titleGlioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium
dc.typeJournal Article
dc.identifier.doi10.1093/neuonc/noy020
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.departmentCentre for Cancer Research
melbourne.source.titleNeuro-Oncology
melbourne.source.volume20
melbourne.source.issue7
melbourne.source.pages873-884
dc.rights.licenseCC BY-NC
melbourne.elementsid1305727
melbourne.contributor.authorGrimmond, Sean
melbourne.contributor.authorGan, Hui
dc.identifier.eissn1523-5866
melbourne.accessrightsOpen Access


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