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dc.contributor.authorDuong, LQ
dc.contributor.authorNguyen, TL
dc.contributor.authorCao, TVA
dc.contributor.authorNguyen, BN
dc.contributor.authorDong, VH
dc.contributor.authorMontgomery, JL
dc.contributor.authorKutcher, SC
dc.contributor.authorNguyen, HL
dc.contributor.authorNguyen, TH
dc.contributor.authorDuong, THK
dc.contributor.authorRabaa, M
dc.contributor.authorO'Neill, SL
dc.contributor.authorSimmons, CP
dc.contributor.authorDang, DA
dc.contributor.authorAnders, KL
dc.date.accessioned2020-12-18T03:34:01Z
dc.date.available2020-12-18T03:34:01Z
dc.date.issued2018-01-01
dc.identifier.citationDuong, L. Q., Nguyen, T. L., Cao, T. V. A., Nguyen, B. N., Dong, V. H., Montgomery, J. L., Kutcher, S. C., Nguyen, H. L., Nguyen, T. H., Duong, T. H. K., Rabaa, M., O'Neill, S. L., Simmons, C. P., Dang, D. A. & Anders, K. L. (2018). Epidemiological, Serological, and Virological Features of Dengue in Nha Trang City, Vietnam. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 98 (2), pp.402-409. https://doi.org/10.4269/ajtmh.17-0630.
dc.identifier.issn0002-9637
dc.identifier.urihttp://hdl.handle.net/11343/255823
dc.description.abstractVietnam is endemic for dengue. We conducted a series of retrospective and prospective studies to characterize the epidemiology of dengue and population mobility patterns in Nha Trang city, Vietnam, with a view to rational design of trials of community-level interventions. A 10-year time series of dengue case notifications showed pronounced interannual variability, as well as spatial heterogeneity in ward-level dengue incidence (median annual coefficient of variation k = 0.47). Of 451 children aged 1-10 years enrolled in a cross-sectional serosurvey, almost one-third had evidence of a past dengue virus (DENV) infection, with older children more likely to have a multitypic response indicative of past exposure to ≥ 1 serotype. All four DENV serotypes were detected in hospitalized patients during 8 months of sampling in 2015. Mobility data collected from 1,000 children and young adults via prospective travel diaries showed that, although all ages spent approximately half of their daytime hours (5:00 am-9:00 pm) at home, younger age groups (≤ 14 years) spent a significantly greater proportion of their time within 500 m of home than older respondents. Together these findings inform the rational design of future trials of dengue preventive interventions in this setting by identifying 1) children < 7 years as an optimal target group for a flavivirus-naive serological cohort, 2) children and young adults as the predominant patient population for a study with a clinical end point of symptomatic dengue, and 3) substantial spatial and temporal variations in DENV transmission, with a consequent requirement for a trial to be large enough and of long enough duration to overcome this heterogeneity.
dc.languageEnglish
dc.publisherAMER SOC TROP MED & HYGIENE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEpidemiological, Serological, and Virological Features of Dengue in Nha Trang City, Vietnam
dc.typeJournal Article
dc.identifier.doi10.4269/ajtmh.17-0630
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleAmerican Journal of Tropical Medicine and Hygiene
melbourne.source.volume98
melbourne.source.issue2
melbourne.source.pages402-409
dc.rights.licenseCC BY
melbourne.elementsid1308443
melbourne.contributor.authorSimmons, Cameron
dc.identifier.eissn1476-1645
melbourne.accessrightsOpen Access


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