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dc.contributor.authorTay, HL
dc.contributor.authorKaiko, GE
dc.contributor.authorPlank, M
dc.contributor.authorLi, J
dc.contributor.authorMaltby, S
dc.contributor.authorEssilfie, A-T
dc.contributor.authorJarnicki, A
dc.contributor.authorYang, M
dc.contributor.authorMattes, J
dc.contributor.authorHansbro, PM
dc.contributor.authorFoster, PS
dc.date.accessioned2020-12-18T03:34:46Z
dc.date.available2020-12-18T03:34:46Z
dc.date.issued2015-04
dc.identifierpii: PPATHOGENS-D-14-00240
dc.identifier.citationTay, H. L., Kaiko, G. E., Plank, M., Li, J., Maltby, S., Essilfie, A. -T., Jarnicki, A., Yang, M., Mattes, J., Hansbro, P. M. & Foster, P. S. (2015). Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.. PLoS Pathog, 11 (4), pp.e1004549-. https://doi.org/10.1371/journal.ppat.1004549.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/255829
dc.description.abstractPathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-microbial machinery of the innate immune system may boost host defence responses. Here we demonstrate that miR-328 is a key element of the host response to pulmonary infection with non-typeable haemophilus influenzae and pharmacological inhibition in mouse and human macrophages augments phagocytosis, the production of reactive oxygen species, and microbicidal activity. Moreover, inhibition of miR-328 in respiratory models of infection, steroid-induced immunosuppression, and smoke-induced emphysema enhances bacterial clearance. Thus, miRNA pathways can be targeted in the lung to enhance host defence against a clinically relevant microbial infection and offer a potential new anti-microbial approach for the treatment of respiratory diseases.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.titleAntagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.1004549
melbourne.affiliation.departmentPharmacology and Therapeutics
melbourne.source.titlePLoS Pathogens
melbourne.source.volume11
melbourne.source.issue4
melbourne.source.pagese1004549-
dc.rights.licenseCC BY
melbourne.elementsid1309734
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404141
melbourne.contributor.authorJarnicki, Andrew
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


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