Show simple item record

dc.contributor.authorBeattie, L
dc.contributor.authorPeltan, A
dc.contributor.authorMaroof, A
dc.contributor.authorKirby, A
dc.contributor.authorBrown, N
dc.contributor.authorColes, M
dc.contributor.authorSmith, DF
dc.contributor.authorKaye, PM
dc.date.accessioned2020-12-18T03:38:03Z
dc.date.available2020-12-18T03:38:03Z
dc.date.issued2010-03-01
dc.identifier.citationBeattie, L., Peltan, A., Maroof, A., Kirby, A., Brown, N., Coles, M., Smith, D. F. & Kaye, P. M. (2010). Dynamic Imaging of Experimental Leishmania donovani-Induced Hepatic Granulomas Detects Kupffer Cell-Restricted Antigen Presentation to Antigen-Specific CD8(+) T Cells. PLOS PATHOGENS, 6 (3), https://doi.org/10.1371/journal.ppat.1000805.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/255853
dc.description.abstractKupffer cells (KCs) represent the major phagocytic population within the liver and provide an intracellular niche for the survival of a number of important human pathogens. Although KCs have been extensively studied in vitro, little is known of their in vivo response to infection and their capacity to directly interact with antigen-specific CD8(+) T cells. Here, using a combination of approaches including whole mount and thin section confocal microscopy, adoptive cell transfer and intra-vital 2-photon microscopy, we demonstrate that KCs represent the only detectable population of mononuclear phagocytes within granulomas induced by Leishmania donovani infection that are capable of presenting parasite-derived peptide to effector CD8(+) T cells. This restriction of antigen presentation to KCs within the Leishmania granuloma has important implications for the identification of new candidate vaccine antigens and for the design of novel immuno-therapeutic interventions.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleDynamic Imaging of Experimental Leishmania donovani-Induced Hepatic Granulomas Detects Kupffer Cell-Restricted Antigen Presentation to Antigen-Specific CD8(+) T Cells
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.1000805
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titlePLoS Pathogens
melbourne.source.volume6
melbourne.source.issue3
dc.rights.licenseCC BY
melbourne.elementsid1312287
melbourne.contributor.authorBeattie, Lynette
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record