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dc.contributor.authorPhillips, R
dc.contributor.authorSvensson, M
dc.contributor.authorAziz, N
dc.contributor.authorMaroof, A
dc.contributor.authorBrown, N
dc.contributor.authorBeattie, L
dc.contributor.authorSignoret, N
dc.contributor.authorKaye, PM
dc.date.accessioned2020-12-18T03:38:11Z
dc.date.available2020-12-18T03:38:11Z
dc.date.issued2010-03-01
dc.identifier.citationPhillips, R., Svensson, M., Aziz, N., Maroof, A., Brown, N., Beattie, L., Signoret, N. & Kaye, P. M. (2010). Innate Killing of Leishmania donovani by Macrophages of the Splenic Marginal Zone Requires IRF-7. PLOS PATHOGENS, 6 (3), https://doi.org/10.1371/journal.ppat.1000813.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/255854
dc.description.abstractHighly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macrophages have been attributed with a variety of functions, including the uptake and clearance of blood and lymph-borne pathogens, little is known about the effector mechanisms they employ after pathogen uptake. Here, we have combined gene expression profiling and RNAi using a stromal macrophage cell line with in situ analysis of the leishmanicidal activity of marginal zone macrophages (MZM) and marginal metallophilic macrophages (MMM) in wild type and gene targeted mice. Our data demonstrate a critical role for interferon regulatory factor-7 (IRF-7) in regulating the killing of intracellular Leishmania donovani by these specialised splenic macrophage sub-populations. This study, therefore, identifies a new role for IRF-7 as a regulator of innate microbicidal activity against this, and perhaps other, non-viral intracellular pathogens. This study also highlights the importance of selecting appropriate macrophage populations when studying pathogen interactions with this functionally diverse lineage of cells.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleInnate Killing of Leishmania donovani by Macrophages of the Splenic Marginal Zone Requires IRF-7
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.1000813
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titlePLoS Pathogens
melbourne.source.volume6
melbourne.source.issue3
dc.rights.licenseCC BY
melbourne.elementsid1312289
melbourne.contributor.authorBeattie, Lynette
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


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