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dc.contributor.authorBowen, AC
dc.contributor.authorCarapetis, JR
dc.contributor.authorCurrie, BJ
dc.contributor.authorFowler, V
dc.contributor.authorChambers, HF
dc.contributor.authorTong, SYC
dc.date.accessioned2020-12-18T03:39:10Z
dc.date.available2020-12-18T03:39:10Z
dc.date.issued2017-09-01
dc.identifierpii: ofx232
dc.identifier.citationBowen, A. C., Carapetis, J. R., Currie, B. J., Fowler, V., Chambers, H. F. & Tong, S. Y. C. (2017). Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess. OPEN FORUM INFECTIOUS DISEASES, 4 (4), https://doi.org/10.1093/ofid/ofx232.
dc.identifier.issn2328-8957
dc.identifier.urihttp://hdl.handle.net/11343/255861
dc.description.abstractSkin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a systematic review of clinical trials and observational studies that address the utility of SXT for SSTI treatment, caused by either GAS or Staphylococcus aureus, including methicillin-resistant (MRSA). We identified 196 studies, and 15 underwent full text review by 2 reviewers. Observational studies, which mainly focused on SSTI due to S aureus, supported the use of SXT when compared with clindamycin or β-lactams. Of 10 randomized controlled trials, 8 demonstrated the efficacy of SXT for SSTI treatment including conditions involving GAS. These findings support SXT use for treatment of impetigo and purulent cellulitis (without an additional β-lactam agent) and abscess and wound infection. For nonpurulent cellulitis, β-lactams remain the treatment of choice.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleSulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess
dc.typeJournal Article
dc.identifier.doi10.1093/ofid/ofx232
melbourne.affiliation.departmentDoherty Institute
melbourne.source.titleOpen Forum Infectious Diseases
melbourne.source.volume4
melbourne.source.issue4
melbourne.identifier.nhmrc1065736
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1298355
melbourne.contributor.authorTong, Steven
dc.identifier.eissn2328-8957
melbourne.identifier.fundernameidNHMRC, 1065736
melbourne.accessrightsOpen Access


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