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dc.contributor.authorLudigs, K
dc.contributor.authorJandus, C
dc.contributor.authorUtzschneider, DT
dc.contributor.authorStaehli, F
dc.contributor.authorBessoles, S
dc.contributor.authorDang, AT
dc.contributor.authorRota, G
dc.contributor.authorCastro, W
dc.contributor.authorZehn, D
dc.contributor.authorVivier, E
dc.contributor.authorHeld, W
dc.contributor.authorRomero, P
dc.contributor.authorGuarda, G
dc.date.accessioned2020-12-18T03:41:37Z
dc.date.available2020-12-18T03:41:37Z
dc.date.issued2016-02-01
dc.identifierpii: ncomms10554
dc.identifier.citationLudigs, K., Jandus, C., Utzschneider, D. T., Staehli, F., Bessoles, S., Dang, A. T., Rota, G., Castro, W., Zehn, D., Vivier, E., Held, W., Romero, P. & Guarda, G. (2016). NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. NATURE COMMUNICATIONS, 7 (1), https://doi.org/10.1038/ncomms10554.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/255880
dc.description.abstractNLRC5 is a transcriptional regulator of MHC class I (MHCI), which maintains high MHCI expression particularly in T cells. Recent evidence highlights an important NK-T-cell crosstalk, raising the question on whether NLRC5 specifically modulates this interaction. Here we show that NK cells from Nlrc5-deficient mice exhibit moderate alterations in inhibitory receptor expression and responsiveness. Interestingly, NLRC5 expression in T cells is required to protect them from NK-cell-mediated elimination upon inflammation. Using T-cell-specific Nlrc5-deficient mice, we show that NK cells surprisingly break tolerance even towards 'self' Nlrc5-deficient T cells under inflammatory conditions. Furthermore, during chronic LCMV infection, the total CD8(+) T-cell population is severely decreased in these mice, a phenotype reverted by NK-cell depletion. These findings strongly suggest that endogenous T cells with low MHCI expression become NK-cell targets, having thus important implications for T-cell responses in naturally or therapeutically induced inflammatory conditions.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleNLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms10554
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleNature Communications
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1304886
melbourne.contributor.authorUtzschneider, Daniel
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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