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dc.contributor.authorKlein, AP
dc.contributor.authorWolpin, BM
dc.contributor.authorRisch, HA
dc.contributor.authorStolzenberg-Solomon, RZ
dc.contributor.authorMocci, E
dc.contributor.authorZhang, M
dc.contributor.authorCanzian, F
dc.contributor.authorChilds, EJ
dc.contributor.authorHoskins, JW
dc.contributor.authorJermusyk, A
dc.contributor.authorZhong, J
dc.contributor.authorChen, F
dc.contributor.authorAlbanes, D
dc.contributor.authorAndreotti, G
dc.contributor.authorArslan, AA
dc.contributor.authorBabic, A
dc.contributor.authorBamlet, WR
dc.contributor.authorBeane-Freeman, L
dc.contributor.authorBerndt, SI
dc.contributor.authorBlackford, A
dc.contributor.authorBorges, M
dc.contributor.authorBorgida, A
dc.contributor.authorBracci, PM
dc.contributor.authorBrais, L
dc.contributor.authorBrennan, P
dc.contributor.authorBrenner, H
dc.contributor.authorBueno-de-Mesquita, B
dc.contributor.authorBuring, J
dc.contributor.authorCampa, D
dc.contributor.authorCapurso, G
dc.contributor.authorCavestro, GM
dc.contributor.authorChaffee, KG
dc.contributor.authorChung, CC
dc.contributor.authorCleary, S
dc.contributor.authorCotterchio, M
dc.contributor.authorDijk, F
dc.contributor.authorDuell, EJ
dc.contributor.authorForetova, L
dc.contributor.authorFuchs, C
dc.contributor.authorFunel, N
dc.contributor.authorGallinger, S
dc.contributor.authorGaziano, JMM
dc.contributor.authorGazouli, M
dc.contributor.authorGiles, GG
dc.contributor.authorGiovannucci, E
dc.contributor.authorGoggins, M
dc.contributor.authorGoodman, GE
dc.contributor.authorGoodman, PJ
dc.contributor.authorHackert, T
dc.contributor.authorHaiman, C
dc.contributor.authorHartge, P
dc.contributor.authorHasan, M
dc.contributor.authorHegyi, P
dc.contributor.authorHelzlsouer, KJ
dc.contributor.authorHerman, J
dc.contributor.authorHolcatova, I
dc.contributor.authorHolly, EA
dc.contributor.authorHoover, R
dc.contributor.authorHung, RJ
dc.contributor.authorJacobs, EJ
dc.contributor.authorJamroziak, K
dc.contributor.authorJanout, V
dc.contributor.authorKaaks, R
dc.contributor.authorKhaw, K-T
dc.contributor.authorKlein, EA
dc.contributor.authorKogevinas, M
dc.contributor.authorKooperberg, C
dc.contributor.authorKulke, MH
dc.contributor.authorKupcinskas, J
dc.contributor.authorKurtz, RJ
dc.contributor.authorLaheru, D
dc.contributor.authorLandi, S
dc.contributor.authorLawlor, RT
dc.contributor.authorLee, I-M
dc.contributor.authorLeMarchand, L
dc.contributor.authorLu, L
dc.contributor.authorMalats, N
dc.contributor.authorMambrini, A
dc.contributor.authorMannisto, S
dc.contributor.authorMilne, RL
dc.contributor.authorMohelnikova-Duchonova, B
dc.contributor.authorNeale, RE
dc.contributor.authorNeoptolemos, JP
dc.contributor.authorOberg, AL
dc.contributor.authorOlson, SH
dc.contributor.authorOrlow, I
dc.contributor.authorPasquali, C
dc.contributor.authorPatel, AV
dc.contributor.authorPeters, U
dc.contributor.authorPezzilli, R
dc.contributor.authorPorta, M
dc.contributor.authorReal, FX
dc.contributor.authorRothman, N
dc.contributor.authorScelo, G
dc.contributor.authorSesso, HD
dc.contributor.authorSeveri, G
dc.contributor.authorShu, X-O
dc.contributor.authorSilverman, D
dc.contributor.authorSmith, JP
dc.contributor.authorSoucek, P
dc.contributor.authorSund, M
dc.contributor.authorTalar-Wojnarowska, R
dc.contributor.authorTavano, F
dc.contributor.authorThornquist, MD
dc.contributor.authorTobias, GS
dc.contributor.authorVan Den Eeden, SK
dc.contributor.authorVashist, Y
dc.contributor.authorVisvanathan, K
dc.contributor.authorVodicka, P
dc.contributor.authorWactawski-Wende, J
dc.contributor.authorWang, Z
dc.contributor.authorWentzensen, N
dc.contributor.authorWhite, E
dc.contributor.authorYu, H
dc.contributor.authorYu, K
dc.contributor.authorZeleniuch-Jacquotte, A
dc.contributor.authorZheng, W
dc.contributor.authorKraft, P
dc.contributor.authorLi, D
dc.contributor.authorChanock, S
dc.contributor.authorObazee, O
dc.contributor.authorPetersen, GM
dc.contributor.authorAmundadottir, LT
dc.date.accessioned2020-12-18T03:43:36Z
dc.date.available2020-12-18T03:43:36Z
dc.date.issued2018-02-08
dc.identifierpii: 10.1038/s41467-018-02942-5
dc.identifier.citationKlein, A. P., Wolpin, B. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Mocci, E., Zhang, M., Canzian, F., Childs, E. J., Hoskins, J. W., Jermusyk, A., Zhong, J., Chen, F., Albanes, D., Andreotti, G., Arslan, A. A., Babic, A., Bamlet, W. R., Beane-Freeman, L., Berndt, S. I. ,... Amundadottir, L. T. (2018). Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-018-02942-5.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/255895
dc.description.abstractIn 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGenome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
dc.typeJournal Article
dc.identifier.doi10.1038/s41467-018-02942-5
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleNature Communications
melbourne.source.volume9
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1305693
melbourne.contributor.authorMilne, Roger
melbourne.contributor.authorSeveri, Gianluca
melbourne.contributor.authorGiles, Graham
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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