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dc.contributor.authorMcCarthny, CR
dc.contributor.authorDu, X
dc.contributor.authorWu, YC
dc.contributor.authorHill, RA
dc.date.accessioned2020-12-18T03:46:37Z
dc.date.available2020-12-18T03:46:37Z
dc.date.issued2018-01-01
dc.identifier.citationMcCarthny, C. R., Du, X., Wu, Y. C. & Hill, R. A. (2018). Investigating the Interactive Effects of Sex Steroid Hormones and Brain-Derived Neurotrophic Factor during Adolescence on Hippocampal NMDA Receptor Expression. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2018, https://doi.org/10.1155/2018/7231915.
dc.identifier.issn1687-8337
dc.identifier.urihttp://hdl.handle.net/11343/255914
dc.description.abstractSex steroid hormones have neuroprotective properties which may be mediated by brain-derived neurotrophic factor (BDNF). This study sought to determine the interactive effects of preadolescent hormone manipulation and BDNF heterozygosity (+/-) on hippocampal NMDA-R expression. Wild-type and BDNF+/- mice were gonadectomised, and females received either 17β-estradiol or progesterone treatment, while males received either testosterone or dihydrotestosterone (DHT) treatment. Dorsal (DHP) and ventral hippocampus (VHP) were dissected, and protein expression of GluN1, GluN2A, GluN2B, and PSD-95 was assessed by Western blot analysis. Significant genotype × OVX interactions were found for GluN1 and GluN2 expression within the DHP of female mice, suggesting modulation of select NMDA-R levels by female sex hormones is mediated by BDNF. Furthermore, within the DHP BDNF+/- mice show a hypersensitive response to hormone treatment on GluN2 expression which may result from upstream alterations in TrkB phosphorylation. In contrast to the DHP, the VHP showed no effects of hormone manipulation but significant effects of genotype on NMDA-R expression. Castration had no effect on NMDA-R expression; however, androgen treatment had selective effects on GluN2B. These data show case distinct, interactive roles for sex steroid hormones and BDNF in the regulation of NMDA-R expression that are dependent on dorsal versus ventral hippocampal region.
dc.languageEnglish
dc.publisherHINDAWI LTD
dc.titleInvestigating the Interactive Effects of Sex Steroid Hormones and Brain-Derived Neurotrophic Factor during Adolescence on Hippocampal NMDA Receptor Expression
dc.typeJournal Article
dc.identifier.doi10.1155/2018/7231915
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleInternational Journal of Endocrinology
melbourne.source.volume2018
dc.rights.licenseCC BY
melbourne.elementsid1308347
melbourne.contributor.authorDu, Xin
melbourne.contributor.authorHill, Rachel
dc.identifier.eissn1687-8345
melbourne.accessrightsOpen Access


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