Difference of uveal parameters between the acute primary angle closure eyes and the fellow eyes
AuthorLi, X; Wang, W; Huang, W; Chen, S; Wang, J; Wang, Z; Liu, Y; He, M; Zhang, X
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sHe, Mingguang
AffiliationOphthalmology (Eye & Ear Hospital)
Document TypeJournal Article
CitationsLi, X., Wang, W., Huang, W., Chen, S., Wang, J., Wang, Z., Liu, Y., He, M. & Zhang, X. (2018). Difference of uveal parameters between the acute primary angle closure eyes and the fellow eyes. EYE, 32 (7), pp.1174-1182. https://doi.org/10.1038/s41433-018-0056-9.
Access StatusOpen Access
PURPOSE: To measure the anterior and posterior ocular biometric characteristics concurrently and to explore the relationship between iris, ciliary body and choroid in acute primary angle closure eyes (APAC) and fellow eyes. METHODS: It is a prospective, cross-sectional study. Thirty patients with recent APAC were finally enroled in it. Anterior and posterior uveal parameters were measured simultaneously by anterior segment optical coherence tomography (AS-OCT), swept-source optical coherence tomography (SS-OCT) and ultrasound biomicroscopy (UBM). The parameters were measured including: pupil diameter (PD); iris thickness, curvature (ICURV), area (IAREA); anterior chamber depth (ACD), width (ACW), area (ACA), volume (ACV); lens vault (LV); choroidal thickness and retinal thickness; maximum ciliary body thickness (CBTmax); ciliary body thickness at the point of the scleral spur (CBT0) and 1000 mm away (CBT1000); anterior placement of the ciliary body (APCB); and trabecular-ciliary angle (TCA). RESULTS: Compared with fellow eyes, APAC eyes had narrower anterior biometric parameters and presented with smaller anterior segment parameters (including ACD and ACW); (p < 0.01)), smaller IAREA and ICURV (p < 0.001), larger LV (p = 0.035), thinner ciliary body and less anterior ciliary process (p < 0.01). After adjustment for potential confounders (axial length, spherical equivalent and PD), APCB was positive correlated with choroidal thickness and CBT, and CBT was positive correlated with choroidal thickness. CONCLUSIONS: Compared with fellow eyes, APAC eyes had narrower anterior biometric parameters, thinner ciliary body and smaller iris area and curvature. APCB, CBT and choroidal thickness were positively correlated. However, further studies are required before these conclusions are generalised.
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