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    Initiation of simple and complex spikes in cerebellar Purkinje cells

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    Author
    Palmer, LM; Clark, BA; Gruendemann, J; Roth, A; Stuart, GJ; Haeusser, M
    Date
    2010-05-15
    Source Title
    The Journal of Physiology
    Publisher
    WILEY-BLACKWELL
    University of Melbourne Author/s
    Palmer, Lucy
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Palmer, L. M., Clark, B. A., Gruendemann, J., Roth, A., Stuart, G. J. & Haeusser, M. (2010). Initiation of simple and complex spikes in cerebellar Purkinje cells. JOURNAL OF PHYSIOLOGY-LONDON, 588 (10), pp.1709-1717. https://doi.org/10.1113/jphysiol.2010.188300.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255933
    DOI
    10.1113/jphysiol.2010.188300
    Abstract
    Cerebellar Purkinje cells produce two distinct forms of action potential output: simple and complex spikes. Simple spikes occur spontaneously or are driven by parallel fibre input, while complex spikes are activated by climbing fibre input. Previous studies indicate that both simple and complex spikes originate in the axon of Purkinje cells, but the precise location where they are initiated is unclear. Here we address where in the axon of cerebellar Purkinje cells simple and complex spikes are generated. Using extracellular recording and voltage-sensitive dye imaging in rat and mouse Purkinje cells, we show that both simple and complex spikes are generated in the proximal axon, 15-20 mum from the soma. Once initiated, simple and complex spikes propagate both down the axon and back into the soma. The speed of backpropagation into the soma was significantly faster for complex compared to simple spikes, presumably due to charging of the somatodendritic membrane capacitance during the climbing fibre synaptic conductance. In conclusion, we show using two independent methods that the final integration site of simple and complex spikes is in the proximal axon of cerebellar Purkinje cells, at a location corresponding to the distal end of the axon initial segment.

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