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    Emerging Roles for VEGF-D in Human Disease

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    Author
    Stacker, SA; Achen, MG
    Date
    2018-03-01
    Source Title
    Biomolecules
    Publisher
    MDPI
    University of Melbourne Author/s
    Stacker, Steven; Achen, Marc
    Affiliation
    Sir Peter MacCallum Department of Oncology
    Metadata
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    Document Type
    Journal Article
    Citations
    Stacker, S. A. & Achen, M. G. (2018). Emerging Roles for VEGF-D in Human Disease. BIOMOLECULES, 8 (1), https://doi.org/10.3390/biom8010001.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255951
    DOI
    10.3390/biom8010001
    Abstract
    Blood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide variety of prevalent diseases in humans. Vascular endothelial growth factor-D (VEGF-D) is a secreted protein that can promote the remodeling of blood vessels and lymphatics in development and disease. Recent fundamental and translational studies have provided insight into the molecular mechanisms by which VEGF-D exerts its effects in human disease. Hence this protein is now of interest as a therapeutic and/or diagnostic target, or as a potential therapeutic agent, in a diversity of indications in cardiovascular medicine, cancer and the devastating pulmonary condition lymphangioleiomyomatosis. This has led to clinical trial programs to assess the effect of targeting VEGF-D signaling pathways, or delivering VEGF-D, in angina, cancer and ocular indications. This review summarizes our understanding of VEGF-D signaling in human disease, which is largely based on animal disease models and clinicopathological studies, and provides information about the outcomes of recent clinical trials testing agonists or antagonists of VEGF-D signaling.

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