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dc.contributor.authorStacker, SA
dc.contributor.authorAchen, MG
dc.date.accessioned2020-12-18T03:51:48Z
dc.date.available2020-12-18T03:51:48Z
dc.date.issued2018-03-01
dc.identifierpii: biom8010001
dc.identifier.citationStacker, S. A. & Achen, M. G. (2018). Emerging Roles for VEGF-D in Human Disease. BIOMOLECULES, 8 (1), https://doi.org/10.3390/biom8010001.
dc.identifier.issn2218-273X
dc.identifier.urihttp://hdl.handle.net/11343/255951
dc.description.abstractBlood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide variety of prevalent diseases in humans. Vascular endothelial growth factor-D (VEGF-D) is a secreted protein that can promote the remodeling of blood vessels and lymphatics in development and disease. Recent fundamental and translational studies have provided insight into the molecular mechanisms by which VEGF-D exerts its effects in human disease. Hence this protein is now of interest as a therapeutic and/or diagnostic target, or as a potential therapeutic agent, in a diversity of indications in cardiovascular medicine, cancer and the devastating pulmonary condition lymphangioleiomyomatosis. This has led to clinical trial programs to assess the effect of targeting VEGF-D signaling pathways, or delivering VEGF-D, in angina, cancer and ocular indications. This review summarizes our understanding of VEGF-D signaling in human disease, which is largely based on animal disease models and clinicopathological studies, and provides information about the outcomes of recent clinical trials testing agonists or antagonists of VEGF-D signaling.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEmerging Roles for VEGF-D in Human Disease
dc.typeJournal Article
dc.identifier.doi10.3390/biom8010001
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titleBiomolecules
melbourne.source.volume8
melbourne.source.issue1
melbourne.identifier.nhmrc1053535
melbourne.identifier.nhmrc1060498
dc.rights.licenseCC BY
melbourne.elementsid1290521
melbourne.contributor.authorStacker, Steven
melbourne.contributor.authorAchen, Marc
dc.identifier.eissn2218-273X
melbourne.identifier.fundernameidNHMRC, 1053535
melbourne.identifier.fundernameidNHMRC, 1060498
melbourne.accessrightsOpen Access


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