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dc.contributor.authorMacdonald, J
dc.contributor.authorHenri, J
dc.contributor.authorRoy, K
dc.contributor.authorHays, E
dc.contributor.authorBauer, M
dc.contributor.authorVeedu, RN
dc.contributor.authorPouliot, N
dc.contributor.authorShigdar, S
dc.date.accessioned2020-12-18T03:52:58Z
dc.date.available2020-12-18T03:52:58Z
dc.date.issued2018-01-01
dc.identifierpii: cancers10010019
dc.identifier.citationMacdonald, J., Henri, J., Roy, K., Hays, E., Bauer, M., Veedu, R. N., Pouliot, N. & Shigdar, S. (2018). EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs. CANCERS, 10 (1), https://doi.org/10.3390/cancers10010019.
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/11343/255960
dc.description.abstractThe epithelial cell adhesion molecule (EpCAM), or CD326, was one of the first cancer associated biomarkers to be discovered. In the last forty years, this biomarker has been investigated for use in personalized cancer therapy, with the first monoclonal antibody, edrecolomab, being trialled in humans more than thirty years ago. Since then, several other monoclonal antibodies have been raised to EpCAM and tested in clinical trials. However, while monoclonal antibody therapy has been investigated against EpCAM for almost 40 years as primary or adjuvant therapy, it has not shown as much promise as initially heralded. In this review, we look at the reasons why and consider alternative targeting options, such as aptamers, to turn this almost ubiquitously expressed epithelial cancer biomarker into a viable target for future personalized therapy.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEpCAM Immunotherapy versus Specific Targeted Delivery of Drugs
dc.typeJournal Article
dc.identifier.doi10.3390/cancers10010019
melbourne.affiliation.departmentClinical Pathology
melbourne.source.titleCancers
melbourne.source.volume10
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1290632
melbourne.contributor.authorPouliot, Normand
dc.identifier.eissn2072-6694
melbourne.accessrightsOpen Access


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