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dc.contributor.authorVan Baak, TE
dc.contributor.authorCoarfa, C
dc.contributor.authorDugue, P-A
dc.contributor.authorFiorito, G
dc.contributor.authorLaritsky, E
dc.contributor.authorBaker, MS
dc.contributor.authorKessler, NJ
dc.contributor.authorDong, J
dc.contributor.authorDuryea, JD
dc.contributor.authorSilver, MJ
dc.contributor.authorSaffari, A
dc.contributor.authorPrentice, AM
dc.contributor.authorMoore, SE
dc.contributor.authorGhantous, A
dc.contributor.authorRoutledge, MN
dc.contributor.authorGong, YY
dc.contributor.authorHerceg, Z
dc.contributor.authorVineis, P
dc.contributor.authorSeveri, G
dc.contributor.authorHopper, JL
dc.contributor.authorSouthey, MC
dc.contributor.authorGiles, GG
dc.contributor.authorMilne, RL
dc.contributor.authorWaterland, RA
dc.date.accessioned2020-12-18T03:53:07Z
dc.date.available2020-12-18T03:53:07Z
dc.date.issued2018-01-09
dc.identifierpii: 10.1186/s13059-017-1374-0
dc.identifier.citationVan Baak, T. E., Coarfa, C., Dugue, P. -A., Fiorito, G., Laritsky, E., Baker, M. S., Kessler, N. J., Dong, J., Duryea, J. D., Silver, M. J., Saffari, A., Prentice, A. M., Moore, S. E., Ghantous, A., Routledge, M. N., Gong, Y. Y., Herceg, Z., Vineis, P., Severi, G. ,... Waterland, R. A. (2018). Epigenetic supersimilarity of monozygotic twin pairs. GENOME BIOLOGY, 19 (1), https://doi.org/10.1186/s13059-017-1374-0.
dc.identifier.issn1474-760X
dc.identifier.urihttp://hdl.handle.net/11343/255961
dc.description.abstractBACKGROUND: Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic variation. The phenotypic and epigenetic similarities of monozygotic twins have been assumed to be largely due to their genetic identity. RESULTS: Here, by analyzing data from a genome-scale study of DNA methylation in monozygotic and dizygotic twins, we identified genomic regions at which the epigenetic similarity of monozygotic twins is substantially greater than can be explained by their genetic identity. This "epigenetic supersimilarity" apparently results from locus-specific establishment of epigenotype prior to embryo cleavage during twinning. Epigenetically supersimilar loci exhibit systemic interindividual epigenetic variation and plasticity to periconceptional environment and are enriched in sub-telomeric regions. In case-control studies nested in a prospective cohort, blood DNA methylation at these loci years before diagnosis is associated with risk of developing several types of cancer. CONCLUSIONS: These results establish a link between early embryonic epigenetic development and adult disease. More broadly, epigenetic supersimilarity is a previously unrecognized phenomenon that may contribute to the phenotypic similarity of monozygotic twins.
dc.languageEnglish
dc.publisherBMC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEpigenetic supersimilarity of monozygotic twin pairs
dc.typeJournal Article
dc.identifier.doi10.1186/s13059-017-1374-0
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentClinical Pathology
melbourne.source.titleGenome Biology
melbourne.source.volume19
melbourne.source.issue1
melbourne.identifier.nhmrc209057
melbourne.identifier.nhmrc1027505
dc.rights.licenseCC BY
melbourne.elementsid1290648
melbourne.contributor.authorSeveri, Gianluca
melbourne.contributor.authorSouthey, Melissa
melbourne.contributor.authorGiles, Graham
melbourne.contributor.authorDugue, Pierre-Antoine
melbourne.contributor.authorHopper, John
melbourne.contributor.authorMilne, Roger
dc.identifier.eissn1474-760X
melbourne.identifier.fundernameidCANCER COUNCIL VICTORIA, 1074383
melbourne.identifier.fundernameidNHMRC, 209057
melbourne.identifier.fundernameidNHMRC, 1027505
melbourne.accessrightsOpen Access


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