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dc.contributor.authorMartelotto, LG
dc.contributor.authorNg, CKY
dc.contributor.authorPiscuoglio, S
dc.contributor.authorWeigelt, B
dc.contributor.authorReis-Filho, JS
dc.date.accessioned2020-12-18T03:56:56Z
dc.date.available2020-12-18T03:56:56Z
dc.date.issued2014-01-01
dc.identifierpii: 10.1186/bcr3658
dc.identifier.citationMartelotto, L. G., Ng, C. K. Y., Piscuoglio, S., Weigelt, B. & Reis-Filho, J. S. (2014). Breast cancer intra-tumor heterogeneity. BREAST CANCER RESEARCH, 16 (3), https://doi.org/10.1186/bcr3658.
dc.identifier.issn1465-542X
dc.identifier.urihttp://hdl.handle.net/11343/255990
dc.description.abstractIn recent years it has become clear that cancer cells within a single tumor can display striking morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic and phenomenological data support the existence of intra-tumor genetic heterogeneity in breast cancers; however, its basis is yet to be fully defined. Two of the most widely evoked concepts to explain the origin of heterogeneity within tumors are the cancer stem cell hypothesis and the clonal evolution model. Although the cancer stem cell model appeared to provide an explanation for the variability among the neoplastic cells within a given cancer, advances in massively parallel sequencing have provided several lines of evidence to suggest that intra-tumor genetic heterogeneity likely plays a fundamental role in the phenotypic heterogeneity observed in cancers. Many challenges remain, however, in the interpretation of the next generation sequencing results obtained so far. Here we review the models that explain tumor heterogeneity, the causes of intra-tumor genetic diversity and their impact on our understanding and management of breast cancer, methods to study intra-tumor heterogeneity and the assessment of intra-tumor genetic heterogeneity in the clinic.
dc.languageEnglish
dc.publisherBMC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleBreast cancer intra-tumor heterogeneity
dc.typeJournal Article
dc.identifier.doi10.1186/bcr3658
melbourne.affiliation.departmentClinical Pathology
melbourne.source.titleBreast Cancer Research
melbourne.source.volume16
melbourne.source.issue3
dc.rights.licenseCC BY
melbourne.elementsid1298294
melbourne.contributor.authorMartelotto, Luciano
dc.identifier.eissn1465-5411
melbourne.accessrightsOpen Access


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