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    Investigation of the Role of Campylobacter Infection in Suspected Acute Polyradiculoneuritis in Dogs

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    Author
    Martinez-Anton, L; Marenda, M; Firestone, SM; Bushell, RN; Child, G; Hamilton, AI; Long, SN; Le Chevoir, MAR
    Date
    2018-01-01
    Source Title
    Journal of Veterinary Internal Medicine
    Publisher
    WILEY
    University of Melbourne Author/s
    Firestone, Simon; Marenda, Marc; Le Chevoir, Matthias; Long, Sam
    Affiliation
    Veterinary Biosciences
    Veterinary Clinical Sciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Martinez-Anton, L., Marenda, M., Firestone, S. M., Bushell, R. N., Child, G., Hamilton, A. I., Long, S. N. & Le Chevoir, M. A. R. (2018). Investigation of the Role of Campylobacter Infection in Suspected Acute Polyradiculoneuritis in Dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE, 32 (1), pp.352-360. https://doi.org/10.1111/jvim.15030.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255994
    DOI
    10.1111/jvim.15030
    Abstract
    BACKGROUND: Acute polyradiculoneuritis (APN) is an immune-mediated peripheral nerve disorder in dogs that shares many similarities with Guillain-Barré syndrome (GBS) in humans, in which the bacterial pathogen Campylobacter spp. now is considered to be a major triggering agent. Little information is available concerning the relationship between APN and Campylobacter spp. in dogs. HYPOTHESIS/OBJECTIVES: To estimate the association between Campylobacter spp. infection and APN. Associations with additional potential risk factors also were investigated, particularly consumption of raw chicken. ANIMALS: Twenty-seven client-owned dogs suffering from suspected APN and 47 healthy dogs, client-owned or owned by staff members. METHODS: Case-control study with incidence density-based sampling. Fecal samples were collected from each enrolled animal to perform direct culture, DNA extraction, and polymerase chain reaction (PCR) for detection of Campylobacter spp. In some cases, species identification was performed by sequence analysis of the amplicon. Data were obtained from the medical records and owner questionnaires in both groups. RESULTS: In cases in which the fecal sample was collected within 7 days from onset of clinical signs, APN cases were 9.4 times more likely to be positive for Campylobacter spp compared to control dogs (P < 0.001). In addition, a significant association was detected between dogs affected by APN and the consumption of raw chicken (96% of APN cases; 26% of control dogs). The most common Campylobacter spp. identified was Campylobacter upsaliensis. CONCLUSIONS AND CLINICAL IMPORTANCE: Raw chicken consumption is a risk factor in dogs for the development of APN, which potentially is mediated by infection with Campylobacter spp.

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