DExSI: a new tool for the rapid quantitation of C-13-labelled metabolites detected by GC-MS
AuthorDagley, MJ; McConville, MJ
PublisherOXFORD UNIV PRESS
AffiliationBiochemistry and Molecular Biology
Document TypeJournal Article
CitationsDagley, M. J. & McConville, M. J. (2018). DExSI: a new tool for the rapid quantitation of C-13-labelled metabolites detected by GC-MS. BIOINFORMATICS, 34 (11), pp.1957-1958. https://doi.org/10.1093/bioinformatics/bty025.
Access StatusOpen Access
NHMRC Grant codeNHMRC/1100000
Summary: Stable isotope directed metabolomics is increasingly being used to measure metabolic fluxes in microbial, plant and animal cells. Incorporation of 13C/15N isotopes into a wide range of metabolites is typically determined using gas chromatography-mass spectrometry (GC/MS) or other hyphenated mass spectrometry approaches. The DExSI (Data Extraction for Stable Isotope-labelled metabolites) pipeline is an interactive graphical software package which can be used to rapidly quantitate isotopologues for a wide variety of metabolites detected by GC/MS. DExSI performs automated metabolite annotation, mass and positional isotopomer abundance determination and natural isotope abundance correction. It provides a range of output options and is suitable for high throughput analyses. Availability and implementation: DExSI is available for non-commercial use from: https://github.com/DExSI/DExSI/. For Microsoft Windows 7 or higher (64-bit). Contact: firstname.lastname@example.org or email@example.com. Supplementary information: Supplementary data are available at Bioinformatics online.
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