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dc.contributor.authorAkinduro, O
dc.contributor.authorWeber, TS
dc.contributor.authorAng, H
dc.contributor.authorHaltalli, MLR
dc.contributor.authorRuivo, N
dc.contributor.authorDuarte, D
dc.contributor.authorRashidi, NM
dc.contributor.authorHawkins, ED
dc.contributor.authorDuffy, KR
dc.contributor.authorLo Celso, C
dc.date.accessioned2020-12-18T04:00:56Z
dc.date.available2020-12-18T04:00:56Z
dc.date.issued2018-02-06
dc.identifierpii: 10.1038/s41467-017-02376-5
dc.identifier.citationAkinduro, O., Weber, T. S., Ang, H., Haltalli, M. L. R., Ruivo, N., Duarte, D., Rashidi, N. M., Hawkins, E. D., Duffy, K. R. & Lo Celso, C. (2018). Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-017-02376-5.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/256015
dc.description.abstractLeukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis by mechanisms that are not fully understood. Combining cell number measurements with a short-timescale dual pulse labelling method, we simultaneously determine the proliferation dynamics of primitive haematopoietic compartments and acute myeloid leukaemia (AML). We observe an unchanging proportion of AML cells entering S phase per hour throughout disease progression, with substantial BM egress at high levels of infiltration. For healthy haematopoiesis, we find haematopoietic stem cells (HSCs) make a significant contribution to cell production, but we phenotypically identify a quiescent subpopulation with enhanced engraftment ability. During AML progression, we observe that multipotent progenitors maintain a constant proportion entering S phase per hour, despite a dramatic decrease in the overall population size. Primitive populations are lost from BM with kinetics that are consistent with ousting irrespective of cell cycle state, with the exception of the quiescent HSC subpopulation, which is more resistant to elimination.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleProliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space
dc.typeJournal Article
dc.identifier.doi10.1038/s41467-017-02376-5
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleNature Communications
melbourne.source.volume9
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1305549
melbourne.contributor.authorHawkins, Edwin
melbourne.contributor.authorWeber, Tom
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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